NUDT2
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Official Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 2 -
Overview
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. -
Synonyms
NUDT2;nudix (nucleoside diphosphate linked moiety X)-type motif 2;APAH1;bis(5-nucleosyl)-tetraphosphatase [asymmetrical];Ap4A hydrolase 1;Ap4Aase;bis(5 nucleosyl) tetraphosphatase (asymmetrical);diadenosine 5;5 P1;P4 tetraphosphate pyrophosphohydrolase;diadenosine tetraphosphatase;2310051L06Rik;AA939917;Ap4A hydrolase;APAH 1;Bis(5 nucleosyl) tetraphosphatase [asymmetrical];Diadenosine 5,5 P1,P4 tetraphosphate asymmetrical hydrolase;Diadenosine 5,5-P1,P4-tetraphosphate pyrophosphohydrolase;EC 3.6.1.17;MGC10404;Nucleoside diphosphate linked moiety X motif 2;Nudix motif 2;Nudix-type motif 2;NUDT 2;OTTHUMP00000021256;OTTHUMP00000021257;OTTHUMP00000021258;OTTHUMP00000021259;nucleoside diphosphate-linked moiety X motif 2;bis(5-nucleosyl
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NUDT2 involved in several pathways and played different roles in them. We selected most pathways NUDT2 participated on our site, such as Purine metabolism,Pyrimidine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyrimidine metabolism | DPYS,NT5M,NME1-NME2,NT5C1AA,DPYD,NME2B.1,CMPK1,PNPT1,NT5C3B,TK1 |
| Purine metabolism | POLE4,PDE1B,POLD2,POLR2J2,POLE2,POLR3C,ENPP3,PRIM2,NME2B.2,ATIC |
Protein Function
NUDT2 has several biochemical functions, for example, GTP binding,bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity,bis(5-nucleosyl)-tetraphosphatase (symmetrical) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT2 itself. We selected most functions NUDT2 had, and list some proteins which have the same functions with NUDT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RAB1,RASD1,GBP5,GTPBP4,GNL2,SEPT11,DIRAS2,NPR2,GBP6,ARL4C |
| protein binding | HSPB8,RAB3A,MLKL,TRMT61B,CARD11,EIF5,PDS5B,PYGB,SPATA8,CALML3 |
Interacting Protein
NUDT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT2.
MCM6;ESR2
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References
- Albayrak, O; Putter, C; et al. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 162B:295-305(2013).
- Szczepanek, J; Styczynski, J; et al. Identification of the genes expression profile associated with the ex vivo resistance to etoposide in childhood acute leukemias. POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ 66:401-408(2012).
