NR4A2
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Official Full Name
nuclear receptor subfamily 4, group A, member 2 -
Overview
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
NR4A2;nuclear receptor subfamily 4, group A, member 2;NOT;RNR1;HZF-3;NURR1;TINUR;nuclear receptor subfamily 4 group A member 2;nuclear receptor related 1;T-cell nuclear receptor NOT;orphan nuclear receptor NR4A2;orphan nuclear receptor NURR1;intermediate-early receptor protein;immediate-early response protein NOT;nur related protein-1, human homolog of;transcriptionally-inducible nuclear receptor;NGFI-B/nur77 beta-type transcription factor homolog;transcriptionally inducible nuclear receptor related 1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Yeast
- Wheat Germ
- Mammalian Cell
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
NR4A2 involved in several pathways and played different roles in them. We selected most pathways NR4A2 participated on our site, such as Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | CALM2,ITPR1,ATF4,PLCB3,CREB3L4,PRKD2,CALML3,CAMK2A,PRKCB,PLCB2 |
Protein Function
NR4A2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR4A2 itself. We selected most functions NR4A2 had, and list some proteins which have the same functions with NR4A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RCOR2,MLL1,PLN,RIPK2,OIP5,INTS10,ZFYVE19,IGFN1,KCNA2,TNP1 |
| steroid hormone receptor activity | NR1H2,NR4A2A,NR1I2,NR2E3,NR6A1A,RARGB,RXRAA,NR1D1,NR2E1,NR2F6 |
| protein homodimerization activity | TENM3,GOLGA5,SNX2,AADAT,LGALS6,NUDT16,RAB11FIP2,ASCL1,MZF1,EFR3A |
| protein heterodimerization activity | Itgam&Itgb2,POU5F3,SOX32,HIST4H4,PVRL1,IKZF2,SOX8,BDKRB2,ITGB1,TLR6 |
| DNA binding | RARAA,HNRPK,ZFML,MGAA,POLR3D,BBX,IRX1B,XRCC6,ZNF557,JUNBA |
| RNA polymerase II core promoter sequence-specific DNA binding | SOX8,YAP1,RREB1,TRP53,FOS,NSD1,SMYD3,H3F3B,SFPI1,STAT5A |
| retinoid X receptor binding | VDR,NRIP1,RARG,NR1H2,NCOA1,HMGA1-RS1,PPARG,NR0B2,NCOR1,NSD1 |
| zinc ion binding | KDM2B,AFG3L2,TRIM39,MSRB2,TRIM5,BMP1A,DHX58,SIRT2,PPARAA,LDB3 |
| glucocorticoid receptor binding | YWHAH,STAT3,EP300,STAT5B,ETS2,NRIP1,GRIP1,CEBPB,FKBP4 |
Interacting Protein
NR4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR4A2.
TCEAL5;NDUFS5;OPA1;NEFM;FDX1;ZNF41;RAN;GTF2I;EIF3A;SUGP2;ANP32E;ZCCHC17;CISD1;BAZ1B
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References
- Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
- Moon, M; Jeong, I; et al. Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY 132:254-262(2015).
