NR4A1
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Official Full Name
nuclear receptor subfamily 4, group A, member 1 -
Overview
Nur77, also known as TR3 and NGFI-B, is an immediate-early response gene and an orphan member of the steroid/thyroid/retinoid receptor superfamily (1-3). Nur77 is composed of an amino-terminal transactivation domain, a central DNA-binding domain and a car -
Synonyms
NR4A1;nuclear receptor subfamily 4, group A, member 1;nuclear receptor subfamily 4 group A member 1;hormone receptor;nuclear protein N10;orphan nuclear receptor HMR;nuclear hormone receptor NUR/77;Hmr;N10;TR3;Gfrp;Hbr1;NP10;TIS1;GFRP1;Hbr-1;NGFIB;nur77;NGFI-B
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- HEK293T
- E. coli
- Yeast
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- N-His&C-Myc
- Flag
Involved Pathway
NR4A1 involved in several pathways and played different roles in them. We selected most pathways NR4A1 participated on our site, such as MAPK signaling pathway,PIK-Akt signaling pathway,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | CYP21A1,ITPR3,PRKACG,ADCY1,PLCB3,MC2R,PRKACA,KCNK3,HSD3B4,CALM1 |
| MAPK signaling pathway | TAOK1,HSPB1,FGF19,MAPK8IP2,KCNA3,TMEM37,TAOK3,CACNB2A,TAOK2,BDNF |
| PIK-Akt signaling pathway | PCK2,TCL1B1,SGK3,PIK3R1,ATF4,PDGFA,RELA,Il4ra,GNB3,PDGFRA |
Protein Function
NR4A1 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR4A1 itself. We selected most functions NR4A1 had, and list some proteins which have the same functions with NR4A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NPAS4,PLAG1,PPARA,MYOG,MAFB,SP1,OTX2,HOXD13,ONECUT2,MAFA |
| protein heterodimerization activity | HIST3H3,H3F3B.1,PPP2R4,NFYBB,HIST2H4A,ITGB1A,DMRT3A,DMBX1,POLA1,HIST1H2BF |
| steroid hormone receptor activity | NR5A2,RXRA,NR1I2,RARAA,ESRRA,RORCB,ESRRB,NR2F1A,RXRBA,RXRGB |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | AHR,NR5A1A,RORCB,NR2F6A,RXRA,PGR,NR2F1B,NR2F5,NR2F6,ESRRA |
| sequence-specific DNA binding | NKX2.5,CUX1,NFIL3-4,ZSCAN10,HSF4,HOXB8,MAEL,OTX1A,CLOCK,HOXA10B |
| protein binding | RPL15,MRPS16,UBE2U,GPI1,TRIM74,COPE,HTR3E,TAG-260,RABL2,TOE1 |
| DNA binding | TRIM30A,RPP21,ZFP41,ZNF157,DDX20,H1FNT,BHLHE41,FOXL1,HMGA1B,CHD6 |
| zinc ion binding | SIVA1,SEC23A,LNPEP,XRN2,LMO7,PIAS1,ADAM15,ADAM21,ZNF184,LMO1 |
Interacting Protein
NR4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR4A1.
BCL2;TP53;GK;386677
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