NPEPPS
-
Official Full Name
aminopeptidase puromycin sensitive -
Overview
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. -
Synonyms
NPEPPS;aminopeptidase puromycin sensitive;puromycin-sensitive aminopeptidase;metalloproteinase MP100;MP100;PSA;puromycin sensitive aminopeptidase;METALLOPROTEASE 100;METALLOPROTEASE MP100;MP 100;OTTHUMP00000229852;OTTHUMP00000229855;cytosol alanyl aminopeptidase;AAP-S
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- HEK293
- Mammalian Cell
- E.coli
- Insect Cell
- Wheat Germ
- His
- His&S
- His&Myc
- GST
- His&Fc&Avi
Involved Pathway
NPEPPS involved in several pathways and played different roles in them. We selected most pathways NPEPPS participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPEPPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing: Ubiquitination & | TRIM50,TRIM9,GAN,TRIM69,MKRN1,TRIM41,TRIM39,UBR1,SH3RF1,RNF14 |
| presentation | STUB1,UBE2V2,RNF19B,UBE2J2,MKRN1,RNF41,ASB10,CD207,SEC23A,HUWE1 |
| Class I MHC mediated antigen processing & | TRIM9,CTSL1,HECTD3,RNF144B,BLMH,RBCK1,ASB7,SEC24A,LRSAM1,WSB1 |
| Immune System | LY86,CD200,CTSK,CD200R2,BTR02,TXN,DEFA6,RAET1E,KLHL20,TRIM8 |
| Adaptive Immune System | SIGLEC7,TRAT1,DYNC1LI2,NRG3,ASB17,OSBPL1A,CD200R3,ARF1,ASB11,ASB14 |
| Proteasome degradation | ASB9,DZIP3,BLMH,FBXO3,WWP1,LRSAM1,UBE2V1,LTN1,LRRC41,TRIM9 |
Protein Function
NPEPPS has several biochemical functions, for example, aminopeptidase activity,hydrolase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPEPPS itself. We selected most functions NPEPPS had, and list some proteins which have the same functions with NPEPPS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | NRXN2A,DZIP1L,GALNTL6,RSAD1,ADAP2,UBR1,CHAMP1,CISD1,NR1D1,NEK2 |
| hydrolase activity | TMPRSS12,HELZ,DUSP8A,SGPP2,EXO5,SIRT3,CAPN5A,DDX39,PPP4CA,ADARB2 |
| zinc ion binding | BTR09,CPSF4,MTA1,ZDHHC6,SAMHD1,MECR,RAI1,AKAP8,BIRC7,VDR |
| aminopeptidase activity | RNPEP,ERAP2,LNPEP,DPP9,CTSH,METAP2B,LTA4H,LAP3,ENPEP,XPNPEP3 |
| peptidase activity | DPEP3,ESPL1,CAPN2L,ATG4C,MMP14B,TMPRSS11F,TMPRSS7,PCSK5B,BAP1,CAPN5A |
| metallopeptidase activity | GM5136,MEP1A.2,BMP1,AMZ2,ADAM10B,BMP1B,C6AST3,NAALADL1,MMP23B,ADAM9 |
Interacting Protein
NPEPPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPEPPS here. Most of them are supplied by our site. Hope this information will be useful for your research of NPEPPS.
Ywhae;Dlg4
Resources
Research Area
Serine Proteases and RegulatorsMetalloproteases and Regulators
Plasmin/Plasminogen and Kallikrein/Kinin Systems
Related Services
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References
- Lee, S; Shea, TB; et al. Regulation of tau proteolysis by phosphatases. BRAIN RESEARCH 1495:30-36(2013).
- Chow, KM; Guan, HJ; et al. Aminopeptidases do not directly degrade tau protein. MOLECULAR NEURODEGENERATION 5:-(2010).
