NOX4
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Official Full Name
NADPH oxidase 4 -
Overview
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants. -
Synonyms
NOX4;NADPH oxidase 4;KOX;KOX 1;kidney oxidase-1;renal NAD(P)H-oxidase;kidney superoxide-producing NADPH oxidase;KOX-1;RENOX
Recombinant Proteins
- Human
- Chicken
- Rat
- Sumatran orangutan
- Mouse
- Pongo Abelii
- E.coli
- Wheat Germ
- Mammalian Cells
- Yeast
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- His&B2M
- His&Fc&Avi
Involved Pathway
NOX4 involved in several pathways and played different roles in them. We selected most pathways NOX4 participated on our site, such as Oxidative Stress,Signaling events mediated by PTP1B,Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spinal Cord Injury | GAP43,AIF1,RGMA,LILRB3,KLK8,RTN4,RTN4R,PTPRZ1,LGALS3,OMG |
| Signaling events mediated by PTP1B | CSN2,YBX1,DOK1 |
| Oxidative Stress | TXNRD2,TXN2,NFIX,JUNBA,NQO1 |
Protein Function
NOX4 has several biochemical functions, for example, NAD(P)H oxidase activity,electron carrier activity,flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOX4 itself. We selected most functions NOX4 had, and list some proteins which have the same functions with NOX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD(P)H oxidase activity | DERL3,CYB5R4,KMO,DUOX2,AIFM1 |
| superoxide-generating NADPH oxidase activity | SH3PXD2AA,NOX5,NOX1,PAX2,NCF1,CYBB,NOX3 |
| oxygen sensor activity | HIF1AN,EGLN2 |
| modified amino acid binding | CBS,CPS1,DPEP1,MUT,MTHFR |
| heme binding | CYP2AD3,NOS1,IDO2,CYP7A1A,CYP4T8,CYP46A1.1,CYP2C37,CYB5A,CYP21A1,CYP2C8 |
| nucleotide binding | HNRNPA0A,UCKL1A,TUBA2,RBM38,MYH11A,HNRNPR,HNRNPL,RASL11A,PRKCHA,HTATSF1 |
| electron carrier activity | ADH5,CYP19A1,NCF1,ACOX1,AIFM1,AKR1A1,HSD17B6,FDX1B,TSTA3,PRKRA |
| flavin adenine dinucleotide binding | LDHD,AOX4,ACOX3,PPOX,IVD,NDOR1,ACAD8,SQLE,KDM1A,AOX3 |
Interacting Protein
NOX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOX4.
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References
- Zhao, WW; Ma, GX; et al. Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-kappa B pathway. VASCULAR PHARMACOLOGY 63:162-172(2014).
- Nayernia, Z; Jaquet, V; et al. New Insights on NOX Enzymes in the Central Nervous System. ANTIOXIDANTS & REDOX SIGNALING 20:2815-2837(2014).
