NLK
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Official Full Name
nemo-like kinase -
Overview
Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3. -
Synonyms
NLK;nemo-like kinase;serine/threonine-protein kinase NLK
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Sf9 Insect Cell
- Insect Cell
- Mammalian Cell
- Insect Cells
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
- His&Myc
Involved Pathway
NLK involved in several pathways and played different roles in them. We selected most pathways NLK participated on our site, such as MAPK signaling pathway,FoxO signaling pathway,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | CTBP2A,WNT1,SFRP4,DKK4,RAC3B,PRKACA,WNT9A,SIAH2L,RAC3A,PRKCG |
| Adherens junction | SRC,PVRL3B,ACTG1,CSNK2B,ACTN3,CTNNA2,WASLB,WASB,CTNNA3,WASL |
| FoxO signaling pathway | MAPK8,INSB,PIK3R1,RAF1B,CCNB2,IRS2,CDKN1BB,MAPK14B,SIRT1,MAPK8B |
| MAPK signaling pathway | RAP1A,FGF13,MAPK8A,HRASB,MAP3K7,MAPK4,GADD45BB,TGFBR1A,EGFRA,MAPK8 |
Protein Function
NLK has several biochemical functions, for example, ATP binding,MAP kinase activity,SH2 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLK itself. We selected most functions NLK had, and list some proteins which have the same functions with NLK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RFC5,KIF3CB,HSP70L,EGFRA,MARK3,HSPA13,CHORDC1,DCLK2,PDK1,CAMK1DA |
| magnesium ion binding | GEM,ICK,ENO3,SRPK2,MARK2,THTPA,NT5C3B,ATP11C,WEE1,NUDT3 |
| protein binding | TRIM69,MANBAL,MRPL23,ADAMTSL4,VEPH1,FAM49B,LIN37,MRPL13,NR2E3,CYGB |
| MAP kinase activity | MAPK14,MAPK6,MAPK12,MAPK8A,MAPK4,MAPK7,MAPK1,MAPK14A,NLK2,MAPK13 |
| ubiquitin protein ligase binding | MDM2,PIAS1,CLU,ZFP746,UBE2S,CUL3,TRIOBP,TXNIP,AXIN2,YWHAE |
| SH2 domain binding | CTR9,LILRB1,SYP,PTK2,CRK,NUP62,SQSTM1,LCK,PAG1,TRPV4 |
| protein serine/threonine kinase activity | PIM3,SRPK1,ACVRL1,LIMK2,ADCK4,MAPK14B,AKT3A,RAF1B,TBK1,SBK3 |
| protein kinase activity | VSIG8B,RASSF2,AKT1,KDRL,SRPK1,STK25A,PRKCG,NTRK3A,TNK2B,MAP3K11 |
| transcription factor binding | ENPP2,FOXA2,CHCHD2,TP53,TRIM6,MYOCD,HES2,CRY1,TLE1,LEF1 |
Interacting Protein
NLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLK here. Most of them are supplied by our site. Hope this information will be useful for your research of NLK.
SMAD4;ZHX3;RCHY1;MAP3K7;N/A
NLK Related Signal Pathway
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References
- Rosenbaek, LL; Assentoft, M; et al. Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. JOURNAL OF PHYSIOLOGY-LONDON 590:6121-6139(2012).
- Gnanapavan, S; Carrol, C; et al. Paraneoplastic opsoclonus-myoclonus associated with metastatic melanoma and anti-neuroleukin (NLK) antibodies. JOURNAL OF NEUROIMMUNOLOGY 197:174-174(2008).
