NFATC3

  • Official Full Name

    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

  • Overview

    The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an

  • Synonyms

    NFATC3;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3;nuclear factor of activated T-cells, cytoplasmic 3;NFAT4;NFATX;NF-ATc3;T cell transcription factor NFAT4;nuclear factor of activated T-cells c3 isoform IE-Xa

Recombinant Proteins

  • Human
  • Mouse
  • E. coli
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • His
  • Non
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
NFATC3-01H Recombinant Human NFATC3 Protein, His-tagged E. coli Human His 900-1035 aa
NFATC3-27538TH Recombinant Human NFATC3 Wheat Germ Human Non 1068 amino acids
NFATC3-29252TH Recombinant Human NFATC3 Wheat Germ Human Non 80 amino acids
NFATC3-3856HCL Recombinant Human NFATC3 293 Cell Lysate HEK293 Human Non
NFATC3-236H Recombinant Human NFATC3 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
NFATC3-339HF Recombinant Full Length Human NFATC3 Protein In Vitro Cell Free System Human Full L. 1068 amino acids
Nfatc3-4389M Recombinant Mouse Nfatc3 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
NFATC3-5888H Recombinant Human NFATC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    NFATC3 involved in several pathways and played different roles in them. We selected most pathways NFATC3 participated on our site, such as MAPK signaling pathway,cGMP-PKG signaling pathway,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hepatitis B STAT5B,PTEN,CYCS,TRP53,PIK3CG,IFNAR1,IKBKE,IFNA7,IRF3,EP300
    B Cell Receptor Signaling Pathway CD81,PTPN18,PDK2B,GRB2,NFATC1,DOK3,CD22,MAP2K2,MAPK1,PPP3CA
    MAPK signaling pathway CACNB2,PDGFB,RAC3A,MAPK14A,TP53,PLA2G4AA,NRAS,GADD45G,Fgf15,HSPA6
    Axon guidance FRS2A,DUSP2,EZRA,CSNK2A1,DUSP1,EFNB3,RHOD,KALRN,ROBO3,EPHA10
    T cell receptor signaling pathway MAP3K14,CBLB,DEF6A,PIK3R1,IKBKB,CARD11,PAK3,TEC,FOS,SLA1
    Oxytocin signaling pathway CACNG7,PPP3CC,PPP3CA,NPR1,CACNA2D4,PRKCB,GNAO1,ACTB,HRAS,CALM1
    HTLV-I infection ANAPC7,POLE,FZD3,TBP,WNT1,ATF3,POLE3,FZD8,HLA-DRB3,CDC20
    cGMP-PKG signaling pathway AGTR1B,PIK3CB,TRPC6,GNA11,CALML5,ATP2B1,GATA4,PIK3R2,MEF2A,ATP1B2
    Wnt signaling pathway NFATC2,LEF1,FZD1,SFRP5,TCF7L1A,CXXC4,WNT11R,FZD3,BAMBIA,RHOAD

    Protein Function

    NFATC3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC3 itself. We selected most functions NFATC3 had, and list some proteins which have the same functions with NFATC3. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding PITX3,SMAD2,IRF4,JUNBB,SOX10,SPI1,FLI1,CTCF,ALS2CR8,BSX
    transcription factor binding PIAS2,FOXA2,PITX2,EPAS1,KAT8,TFDP1B,JUND,TP53,NKX3,PELP1
    protein binding MIS18A,CPSF3,MAB21L1,PKP1,SPAG8,EPB41B,TBATA,SIPA1L2,ALDH18A1,F2
    chromatin binding KLHDC3,SOX15,REST,GLI3,YAP1,GPR30,PHF21B,ATAD2B,ZFP354B,JUN
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ZFP292,MYOG,GLI3,EGR1,GCM1,NEUROG3,ONECUTL,FOSL1,POU1F1,TFE3B

    Interacting Protein

    NFATC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC3.

    CDK6;RAF1

    NFATC3 Related Signal Pathway

    Resources

    Research Area

    Transcription Regulators in VSMC
    T Cell Cytokine Signaling
    C-type Lectin Receptors

    References

    • Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
    • Dong, YP; Pan, QX; et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 446:85-90(2014).

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