NEUROG3
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Official Full Name
neurogenin 3 -
Overview
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4). -
Synonyms
NEUROG3;neurogenin 3;neurogenin-3;Atoh5;bHLHa7;Math4B;ngn3;ATH4B;Class A basic helix-loop-helix protein 7;NGN-3;NGN3_HUMAN;OTTHUMP00000019730;Protein atonal homolog 5
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- N-His&C-Myc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NEUROG3 involved in several pathways and played different roles in them. We selected most pathways NEUROG3 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEUROG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | HHEX,MNX1,INS2,FOXA3,NR5A2,HNF4A,INS,NKX6-1,PKLR,HES1 |
Protein Function
NEUROG3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin DNA binding,core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEUROG3 itself. We selected most functions NEUROG3 had, and list some proteins which have the same functions with NEUROG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MAFA,SOX1,OVOL1,MYF5,ZSCAN21,TXK,ELF3,CEBPB,NKX6-2,HNRNPK |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZNF217,SNAI2,GATA1,PYDC3,ZFPM1,NKX3-2,ZBTB20,NKX6,ZBTB7A,TFAP2C |
| protein dimerization activity | EBF1,POLR2J2,HER7,ATOH1,NPAS4,POLR1D,MYCA,POLR2C,MEF2CB,SIM1 |
| transcription coactivator activity | HIF3A,VGLL2,COPS5,PQBP1,TDRD3,ZSCAN1,SIX3,ABT1,TAF1,SMARCC2 |
| core promoter binding | NOTCH1,FOXP3,SAFB,HDAC2,NKX3,XBP1,E2F8,SFPI1,NKX3-1,MED1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | YBX1,STAT3,SFPI1,NCOA3,PLSCR1,POU3F2,TXK,FOXJ1,EBF3A,ETV6 |
| protein binding | PLXDC1,INTS7,HEMGN,SNCAIP,MYL7,CIZ1,KLK8,KRT2,YTHDF3,DDX39B |
| chromatin DNA binding | ATOH1,HIST1H1B,AASS,GRHL1,RELA,HDAC3,INSM1B,SRF,XBP1,PER1 |
Interacting Protein
NEUROG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEUROG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEUROG3.
REL;TCF12
Resources
Research Area
Pancreatic Endoderm Cell MarkersPancreatic Progenitor Cell Transcription Factors
Transcription Factors in the Akt Pathway
Epithelial Stem Cell Transcription Factors
Hepatic and Pancreatic Progenitor Cell Transcription Factors
Neural Crest Cell Markers
Endodermal Lineage Markers
Related Services
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References
