NEIL1
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Official Full Name
nei endonuclease VIII-like 1 (E. coli) -
Overview
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme;participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily;oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NEIL1;nei endonuclease VIII-like 1 (E. coli);endonuclease 8-like 1;FLJ22402;FPG1;hFPG1;NEI1;DNA (apurinic or apyrimidinic site) lyase Neil1;DNA glycosylase/AP lyase Neil 1;Endonuclease 8 like 1;endonuclease VIII;Endonuclease VIII like 1;NEH 1;NEH1;NEI 1;Nei endonuclease VIII like 1 (E. coli);Nei endonuclease VIII like 1;Nei homolog 1;Nei like 1;Nei like protein 1;NEIL 1;nei-like protein 1;endonuclease VIII-like 1;DNA glycosylase/AP lyase Neil1;DNA-(apurinic or apyrimidinic site) lyase Neil1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
- His&SUMO
Involved Pathway
NEIL1 involved in several pathways and played different roles in them. We selected most pathways NEIL1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEIL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | POLD4,TDG.1,nth,NEIL2,NTHL1,POLD2,NEIL3,PARP1,FEN1,XRCC1 |
Protein Function
NEIL1 has several biochemical functions, for example, DNA N-glycosylase activity,DNA-(apurinic or apyrimidinic site) lyase activity,damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEIL1 itself. We selected most functions NEIL1 had, and list some proteins which have the same functions with NEIL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | KSR1,ERCC4,PEX5,DBNL,CLIC6,KCNK3,PHB2,EP300,HIC2,SDCBP |
| damaged DNA binding | TP63,HMGB2,TRP53,BRCA1,RPA3,RAD18,TRPC2,ERCC4,RPA2,EP300 |
| DNA N-glycosylase activity | NEIL3,NTHL1,SMUG1,OGG1,TDG |
| hydrolase activity, acting on glycosyl bonds | SPACA5,HYAL6,SMPD1,MAN1A,SMPDL3A,LCTLB,GALCA,MUTYH,MACROD1,UNGA |
| zinc ion binding | PTER,CA3,NANOS1,DPEP1,SCEL,RXRA,NR2C2,DNLZ,MTF2,CAD |
| DNA-(apurinic or apyrimidinic site) lyase activity | NTHL1,HMGA1A,APEX1,NEIL2,APLF,HMGA1,HMGA2,ALKBH1,RPS3,NEIL3 |
Interacting Protein
NEIL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEIL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEIL1.
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