NEFH
-
Official Full Name
neurofilament, heavy polypeptide -
Overview
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. -
Synonyms
NEFH;neurofilament, heavy polypeptide;neurofilament heavy polypeptide;NF-H;200 kDa neurofilament protein;neurofilament triplet H protein;Nfh
Recombinant Proteins
- Human
- Pig
- Bovine
- Rat
- Mouse
- E. coli
- HEK293
- Baculovirus-Insect cells
- E.coli
- bovine Spinal Cord
- HEK293T
- Mammalian cells
- His
- Myc&DDK
- His&GST
- His&SUMO
- His&Fc&Avi
- Non
- His&Myc&SUMO
- Flag
- N-His&C-Myc
Involved Pathway
NEFH involved in several pathways and played different roles in them. We selected most pathways NEFH participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amyotrophic lateral sclerosis (ALS) | MAPK14,DAXX,MAP3K5,PPP3R1,PPP3CA,ALS2,PRPH,MAP2K3,GRIN2C,TRP53 |
Protein Function
NEFH has several biochemical functions, for example, dynein binding,kinesin binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFH itself. We selected most functions NEFH had, and list some proteins which have the same functions with NEFH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of cytoskeleton | EPB41,TUBG1,TUBD1,DES,VIM,TUBA1L,TUBA3D,TUBE1,ACTA1,SPTB |
| structural molecule activity | CLDN2,KRT31,SPRR3,CLDNI,CLDN8,MAP7,IVL,KRT93,COL18A1,COPE |
| kinesin binding | DISC1,TOR1A,KLC3,SERPINB1A,SPAG9A,JIP1,IFT88,SNCA,SPAG9,AP1G1 |
| microtubule binding | KIF23,KCNH2A,KIF22,PAFAH1B1,CNN3,KLC3,LRPPRC,KIF2A,MAP1LC3B,CLIP1 |
| protein heterodimerization activity | HIST1H2BN,KCNB2,HOMER2,HIST1H2A9,TCF3,UBXN6,POLA1,CABYR,NR4A2,DDIT3 |
| protein kinase binding | TRAP1,CALM,PRKAG2,SPDYB,PTPN6,STK39,CCNA2,SNAP91,RPS6KA3,DAXX |
| toxic substance binding | GUCY2C,EPHX2,PHAX,DSG1,Alb,AZU1,ASS1,CHRNA7,H2-AB1,A4GALT |
| protein binding, bridging | GATAD2A,PPP2R3A,GOLGA5,ADAP2,CAV1,FSCN2A,BCL3,NMD3,PSMC6,FKBP4 |
| dynein binding | PAFAH1B1B,KATNA1,DCTN6,PAFAH1B1,SNCA,SMC3,WDR81,DNAAF1,LRRC50,DCTN1 |
Interacting Protein
NEFH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFH here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFH.
UL36;d2cfj1_9flav;M84;NS;k1_vaccw;ICP0;P/V/C;e3_vaccw;polg_den27;RL1;GRB2;VP35;ESR2;P/V/C
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