NEDD8
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Official Full Name
neural precursor cell expressed, developmentally down-regulated 8 -
Overview
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. -
Synonyms
NEDD8;neural precursor cell expressed, developmentally down-regulated 8;Nedd 8;neddylin;ubiquitin-like protein Nedd8;NEDD-8;FLJ43224;MGC104393;MGC125896;MGC125897
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Human
- E. coli
- HEK293
- GST
- Non
- His
- His&SUMO
- His&Fc&Avi
Involved Pathway
NEDD8 involved in several pathways and played different roles in them. We selected most pathways NEDD8 participated on our site, such as Signal Transduction,Signaling by TGF-beta Receptor Complex,TGF-beta receptor signaling activates SMADs, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEDD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | PDE10A,ADH8B,HECW1,PRICKLE1,RYK,SOX6,PTH,GPR77,BCL9L,SOX9B |
| p53 pathway | TRIM28,SMYD2,PPP1R13L,E4F1,CSNK1G3,FBXO11,KAT8,RASSF1,TTC5,CSE1L |
| Signaling by TGF-beta Receptor Complex | SKIB,STRAP,SKIA,NEDD8L,USP9,CGNB,USP15,UCHL5,SKILB,USP9X |
| TGF-beta receptor signaling activates SMADs | PMEPA1,NEDD8L,STRAP,UCHL5,USP15 |
Protein Function
NEDD8 has several biochemical functions, for example, protein binding,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEDD8 itself. We selected most functions NEDD8 had, and list some proteins which have the same functions with NEDD8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | PRDX6,SKI,RNF40,CUL1B,CUL1,FZD8,PIAS2,UBE2L3,GLMN,PARK2 |
| protein binding | TOMM70A,MBP,LZTS1,TOM1,COPB1,USH1G,LARP1,FLI1,CRK,ZC3HAV1 |
Interacting Protein
NEDD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEDD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEDD8.
CUL1;UBE2M;RPL11;NAE1;CUL5
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References
- Wang, Q; Burles, K; et al. Ectromelia Virus Encodes a BTB/kelch Protein, EVM150, That Inhibits NF-kappa B Signaling. JOURNAL OF VIROLOGY 88:4853-4865(2014).
- Amaral, AT; Ordonez, JL; et al. Innovative Therapies in Ewing Sarcoma. ADVANCES IN ANATOMIC PATHOLOGY 21:44-62(2014).
