NDUFA2
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- Overview
- Review / Q&A
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa -
Overview
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants. -
Synonyms
NDUFA2;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 (8kD, B8);NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;B8;complex I B8 subunit;CD 14;CD14;CI B8;Complex I B8;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 8kDa;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2;NADH ubiquinone oxidoreductase B8 subunit;NDUFA 2;OTTHUMP00000159890;OTTHUMP00000223709;NADH-ubiquinone oxidoreductase subunit CI-B8;CIB8
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Chicken
- Cynomolgus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
NDUFA2 involved in several pathways and played different roles in them. We selected most pathways NDUFA2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | TKTL2,PCK1,ALDH1B1,IDUA,ITPKA,P4HA1A,MAT2B,MTHFD1,RDH8,EPRS |
| Alzheimers disease | CASP9,NDUFB7,FAS,NDUFS6,NDUFA4L2,COX5A,MME,GAPDH,GRIN2C,ATP2A1 |
| Non-alcoholic fatty liver disease (NAFLD) | SREBF1,NDUFS8,NDUFS1,DDIT3,IL1B,ADIPOR1,SDHC,PRKAG2,MAP3K11,IL-8 |
| Oxidative phosphorylation | ATP6V0A2,NDUFA13,NDUFB5,NDUFS6,ATP6V0D2,ATP5IB,NDUFA4L2,COX7A3,NDUFA3,UQCR10 |
| Parkinsons disease | NDUFS2,NDUFA7,GNAI2,NDUFB4,SDHD,NDUFC2-KCTD14,UQCRB,NDUFV3,PARK7,GNAI3 |
| Huntingtons disease | PLCB2,DNAI2,PLCB1,NDUFB8,DNAL1,NDUFB6,SDHA,SLC25A6,POLR2D,COX7B2 |
Protein Function
NDUFA2 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFA2 itself. We selected most functions NDUFA2 had, and list some proteins which have the same functions with NDUFA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFA1,NDUFB4,NDUFA9,NDUFC2-KCTD14,NDUFA7,NDUFA5,NDUFB2,NDUFA13,NDUFB7,NDUFA10 |
Interacting Protein
NDUFA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFA2.
NDUFS4;NDUFS5;NDUFS3;NDUFV1;NDUFA6;NDUFA9;NDUFA11
Resources
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References
- Han, SJ; Zhu, Y; et al. The differently expressed proteins in MSCs of degenerative scoliosis. JOURNAL OF ORTHOPAEDIC SCIENCE 18:885-892(2013).
- Li, YG; Zhu, W; et al. Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438:270-276(2013).
