NDUFA2

  • Product List
  • Overview
  • Review / Q&A
  • Official Full Name

    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
  • Overview

    The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.
  • Synonyms

    NDUFA2;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 (8kD, B8);NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;B8;complex I B8 subunit;CD 14;CD14;CI B8;Complex I B8;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 8kDa;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2;NADH ubiquinone oxidoreductase B8 subunit;NDUFA 2;OTTHUMP00000159890;OTTHUMP00000223709;NADH-ubiquinone oxidoreductase subunit CI-B8;CIB8

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Zebrafish
  • Chicken
  • Cynomolgus
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
NDUFA2-1222H Recombinant Human NDUFA2 protein, GST-tagged E.coli Human GST
NDUFA2-10515M Recombinant Mouse NDUFA2 Protein Mammalian Cells Mouse His
NDUFA2-2974R Recombinant Rhesus monkey NDUFA2 Protein, His-tagged Mammalian Cells Rhesus macaque His
NDUFA2-3021Z Recombinant Zebrafish NDUFA2 Mammalian Cells Zebrafish His
NDUFA2-5620C Recombinant Chicken NDUFA2 Mammalian Cells Chicken His
NDUFA2-7202H Recombinant Human NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa, His-tagged E.coli Human His 1-99aa
NDUFA2-733C Recombinant Cynomolgus NDUFA2 Protein, His-tagged Mammalian Cells Cynomolgus His
NDUFA2-3921HCL Recombinant Human NDUFA2 293 Cell Lysate HEK293 Human Non
NDUFA2-2194H Recombinant Human NDUFA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
NDUFA2-2793R Recombinant Rhesus Macaque NDUFA2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
NDUFA2-2793R-B Recombinant Rhesus Macaque NDUFA2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Ndufa2-4329M Recombinant Mouse Ndufa2 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
NDUFA2-477C Recombinant Cynomolgus Monkey NDUFA2 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
NDUFA2-477C-B Recombinant Cynomolgus Monkey NDUFA2 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
NDUFA2-5194H Recombinant Human NDUFA2 protein, GST-tagged E.coli Human GST 4-99aa
NDUFA2-5966M Recombinant Mouse NDUFA2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
NDUFA2-5966M-B Recombinant Mouse NDUFA2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

Involved Pathway

NDUFA2 involved in several pathways and played different roles in them. We selected most pathways NDUFA2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers disease MT-ATP6,CALM1,ATP5B,UQCRQ,ATP5F1,PLCB4,TNF,NDUFS6,PLCB1,BID
Parkinsons disease SLC25A4,COX7B2,SLC18A2,CYCS,NDUFA13,UBA1,SDHB,NDUFS2,VDAC2,ATP5G1
Oxidative phosphorylation ATP5H,NDUFS1,ATP5A1,NDUFB1,NDUFS3,ATP5I,ATP6V0CB,COX7A2A,NDUFA6,ctaG
Metabolic pathways PYGM,GCNT2,COX4I2,NSDHL,CHSY1,GMPS,HSD17B7,CYP19A1,CHDH,CYP51
Huntingtons disease COX6A2,POLR2D,VDAC2,PLCB4,ATP5J,UQCRC1,SDHB,SLC25A5,NDUFB10,NDUFA10
Non-alcoholic fatty liver disease (NAFLD) COX7B2,NDUFS5,Casp3,TRAF2,PIK3R5,NFKB1,BID,ATF4,UQCRFS1,PRKAB1

Protein Function

NDUFA2 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFA2 itself. We selected most functions NDUFA2 had, and list some proteins which have the same functions with NDUFA2. You can find most of the proteins on our site.

Function Related Protein
NADH dehydrogenase (ubiquinone) activity NDUFV1,NDUFA1,NDUFS2,NDUFB8,NDUFB10,NDUFB7,NDUFA5,NDUFS5,NDUFC1,NDUFA13

Interacting Protein

NDUFA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFA2.

NDUFS4;NDUFS5;NDUFS3;NDUFV1;NDUFA6;NDUFA9;NDUFA11

Resources

References

  • Han, SJ; Zhu, Y; et al. The differently expressed proteins in MSCs of degenerative scoliosis. JOURNAL OF ORTHOPAEDIC SCIENCE 18:885-892(2013).
  • Li, YG; Zhu, W; et al. Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438:270-276(2013).

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