NDE1
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Official Full Name
nudE nuclear distribution gene E homolog 1 (A. nidulans) -
Overview
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Alternative splicing results in multiple transcript variants. -
Synonyms
NDE1;nudE nuclear distribution gene E homolog 1 (A. nidulans);nuclear distribution protein nudE homolog 1;FLJ20101;NUDE;HOM TES 87;LIS1 interacting protein NUDE1rat homolog;LIS1 interacting protein NUDE1;NDE 1;NDE1_HUMAN;Nuclear distribution gene E homolog 1;NUDE 1;NudE nuclear distribution gene E homolog 1;NUDE1;OTTHUMP00000160329;OTTHUMP00000160330;LIS1-interacting protein NUDE1, rat homolog;LIS4;HOM-TES-87
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- E. coli
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&Myc
Involved Pathway
NDE1 involved in several pathways and played different roles in them. We selected most pathways NDE1 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | CNGA2,MAPRE1B,CEP290,KIFAP3,DYNC1I2,ARL3,HDAC6,TCTEX1D2,DYNLL2A,HSPB11 |
| Cell Cycle, Mitotic | CDKN2D,DYNC1H1,RBBP4,GINS2,TUBGCP4,CNEP1R1,KIF2C,CENPE,POLD3,ERCC6L |
| Cell cycle | RNF168,SMC1A,CUL1B,ORC5,DHFR,CEP164,NIPBLA,CDC25A,FZR1A,MPEG1.1 |
| Centrosome maturation | SSNA1,TUBGCP3,CDK11B,CDK11A,CEP135,DCTN2,CEP63,CEP72,DCTN3,ODF2B |
| Anchoring of the basal body to the plasma membrane | ODF2,FBF1,CLASP1A,CLASP1,NEK2,TUBG1,NEDD1,IQCB1,DCTN1A,NPHP4 |
| Loss of Nlp from mitotic centrosomes | CEP70,HAUS2,SSNA1,CEP76,CEP290,SDCCAG8,CEP72,PCM1,CP110,MAPRE1B |
| Loss of proteins required for interphase microtubule organizationfrom the centrosome | CCP110,CEP152,NEDD1,SSNA1,CENPJ,DCTN1A,CEP76,MAPRE1A,TSGA14,CEP290 |
| G2/M Transition | LIN9,TCTN2,BORA,CEP164,CDK11B,CEP152,CCP110,DYNC1I2,FOXM1,CP110 |
Protein Function
NDE1 has several biochemical functions, for example, identical protein binding,microtubule binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDE1 itself. We selected most functions NDE1 had, and list some proteins which have the same functions with NDE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SYNE1,ALK,FAS,S100A2,DCP1A,BNIP3,GNPNAT1,PTS,PCBD1,CORO1B |
| protein binding | CEP68,BIRC5,ARHGEF12,C5orf24,NR1H2,MDM2,CXCL10,HIST1H4G,RCN1,PPARGC1A |
| protein domain specific binding | CHMP2B,RAP2B,MLF1,ZBTB16,CHMP1A,LIN7C,ZFP521,IGBP1,CNTLN,RAPGEF3 |
| microtubule binding | CENPE,FTCD,FMR1,TRPV4,WDR43,KIF5AA,EML2,KIAA1128,CEP57,SKA2 |
Interacting Protein
NDE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDE1.
Pafah1b1;ZNF365;CDK1;CENPF;Nde1;q81ks6_bacan;Ccser2;AMZ2;APIP;LCOR;CLPTM1L;DCAF13
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References
- Lee, JY; Kang, CD; et al. Engineering Cellular Redox Balance in Saccharomyces cerevisiae for Improved Production of L-Lactic Acid. BIOTECHNOLOGY AND BIOENGINEERING 112:751-758(2015).
- Okamoto, M; Iguchi, T; et al. DBZ Regulates Cortical Cell Positioning and Neurite Development by Sustaining the Anterograde Transport of Lis1 and DISC1 through Control of Ndel1 Dual-Phosphorylation. JOURNAL OF NEUROSCIENCE 35:2942-2958(2015).
