NCS1
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Official Full Name
neuronal calcium sensor 1 -
Overview
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.<br/>Mouse monoclonal antibody raised against a full-length recombinant FREQ. -
Synonyms
FLUP;FREQ;DKFZp761L1223;neuronal calcium sensor 1;frequenin homolog;OTTHUMP00000022356;frequenin-like protein;frequenin-like ubiquitous protein;NCS1;neuronal calcium sensor 1
Recombinant Proteins
- Mouse
- Human
- Chicken
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NCS1-10491M | Recombinant Mouse NCS1 Protein | Mammalian Cell | Mouse | His |
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| NCS1-2353H | Recombinant Human Neuronal Calcium Sensor 1, His-tagged | E.coli | Human | His |
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| NCS1-29296TH | Recombinant Human NCS1, His-tagged | E.coli | Human | His | 190 amino acids |
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| NCS1-29298TH | Recombinant Human NCS1, His-tagged | E.coli | Human | His | Full L. 1-190 a.a. |
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| NCS1-637H | Recombinant Human NCS1 | Mammalian Cell | Human | His |
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| NCS1-6929C | Recombinant Chicken NCS1 | Mammalian Cell | Chicken | His |
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| NCS1-3939HCL | Recombinant Human NCS1 293 Cell Lysate | HEK293 | Human | Non |
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| NCS1-2929H | Recombinant Human NCS1 protein, GST-tagged | E.coli | Human | GST | 1-190aa |
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| NCS1-3595H | Recombinant Human NCS1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NCS1-3595H-B | Recombinant Human NCS1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Ncs1-4318M | Recombinant Mouse Ncs1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| NCS1-4492H | Recombinant Human NCS1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NCS1-5145HF | Recombinant Full Length Human NCS1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 190 amino acids |
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| NCS1-5948M | Recombinant Mouse NCS1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NCS1-5948M-B | Recombinant Mouse NCS1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NCS1 involved in several pathways and played different roles in them. We selected most pathways NCS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NCS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NCS1 has several biochemical functions, for example, calcium ion binding,magnesium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCS1 itself. We selected most functions NCS1 had, and list some proteins which have the same functions with NCS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated calcium channel activity | RYR1,CACNG7A,NALCN,CATSPER1,CACNB2B,CACNA2D2,CACNG3,CACNA1SB,CACNG1,CACNG6 |
| magnesium ion binding | FEN1,EYA2,SNRK,NIM1K,CIB2,ABL1,CDC42BPB,FOXK2,COMT,NT5C1AA |
| calcium ion binding | PCDH18A,SYT5,SPNA1,ZZEF1,TBC1D8B,PPP3CA,DSG4,CCDC47,AMY2A,MYL2 |
| protein kinase binding | CEP68,PTPN23,PAX6,DAXX,TRPV4,PTPRC,TCTN2,AKAP1,MAP3K2,CCNT2B |
| protein binding | ZNF434,KIAA1199,PLAUR,NFKBIE,THEM5,C11orf54,SELP,HMG20B,UBE2I,OTX2 |
Interacting Protein
NCS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCS1.
DTX2;NBL1;DTX2
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References
- Simmons, KJ; Jackson, SM; et al. Molecular mechanism of ligand recognition by membrane transport protein, Mhp1. EMBO JOURNAL 33:1831-1844(2014).
- Guedan, S; Chen, X; et al. ICOS-based chimeric antigen receptors program bipolar T(H)17/T(H)1 cells. BLOOD 124:1070-1080(2014).
