NCR3
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Official Full Name
natural cytotoxicity triggering receptor 3 -
Overview
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5 untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NCR3;natural cytotoxicity triggering receptor 3;LY117, lymphocyte antigen 117;1C7;CD337;NKp30;Natural killer cell p30 related protein;CD337 antigen;LY117;Lymphocyte antigen 117;NK-p30;OTTHUMP00000029162;OTTHUMP00000029163;OTTHUMP00000029164;OTTHUMP00000029165;activating NK-A1 receptor;activating natural killer receptor p30;natural killer cell p30-related protein;MALS
Recombinant Proteins
- Human
- Cynomolgus
- Rat
- Rhesus macaque
- Pan troglodytes
- Macaca fascicularis
- Human Cell
- HEK293
- E.coli
- Mammalian Cell
- Human Cells
- Mammalian cells
- E.coli expression system
- His&Fc
- His
- Fc
- lFc
- His&T7
- Non
- His&Avi
- His&Fc&Avi
Involved Pathway
NCR3 involved in several pathways and played different roles in them. We selected most pathways NCR3 participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | RAET1L,KIR2DS4,HLA-B,MICB,IFNA13,TNFRSF10D,KLRC1,CD48,PIK3CA,MAPK3 |
Protein Function
NCR3 has several biochemical functions, for example, cell adhesion molecule binding,protein homodimerization activity,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCR3 itself. We selected most functions NCR3 had, and list some proteins which have the same functions with NCR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesion molecule binding | NLGN4X,PKP3,MSN,DSG2,PVRL1,CXADR,PVR,LPHN1,CPE,CADM1A |
| receptor binding | WNT4B,HAMP,NRG4,DRD1A,FGF1B,HAO1,CD86,NPPB,TENM2,MLYCD |
| receptor activity | CADM2,P2RY11,VMN1R47,RPA1,F2RL1,NOTCH1A,CD4,NEO1,F2RL1.2,CHRM3 |
| protein homodimerization activity | PTS,DMRT1,SETMAR,TESC,CHMP4A,CARD9,SLC14A2,SEPHS1,SDCBP2,CREB3L3 |
Interacting Protein
NCR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCR3.
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesNatural Killer (NK) Cell CD Antigen
Natural Killer Cell (NK Cell)
Natural Killer T (NKT) Cells
Related Services
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References
