NCF4
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Official Full Name
neutrophil cytosolic factor 4, 40kDa -
Overview
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
NCF4;neutrophil cytosolic factor 4, 40kDa;neutrophil cytosolic factor 4 (40kD);neutrophil cytosol factor 4;neutrophil NADPH oxidase factor 4;p40phox;SH3PXD4;NCF-4;p40-phox;SH3 and PX domain-containing protein 4;NCF;MGC3810
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
NCF4 involved in several pathways and played different roles in them. We selected most pathways NCF4 participated on our site, such as Phagosome,Osteoclast differentiation,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leishmaniasis | TNF,H2-AA,FCGR1,FCGR1A,ITGAM,MYD88,TLR4,PTGS2,HLA-DRB4,IL12B |
| Phagosome | Pla2r1,HLA-DMA,RAB7B,NOS1,ATP6V0CA,TUBA8L2,CALRL2,CALR,MSR1,ATP6V1F |
| Leukocyte transendothelial migration | OCLN,ROCK1,ITGB1,PIK3CB,EZR,VAV1,RHOA,ITGB2,ROCK2,PLCG1 |
| Osteoclast differentiation | IL1B,IFNAR2,LILRB5,SOCS1,TRAF6,GAB2,MAP2K1,PPP3CB,FYN,MAP3K7 |
Protein Function
NCF4 has several biochemical functions, for example, phosphatidylinositol-3-phosphate binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCF4 itself. We selected most functions NCF4 had, and list some proteins which have the same functions with NCF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CREB3,SEC23IP,ZBTB24,BAG1,PPARD,ZNF256,HEBP2,FAM193B,TRAF3IP3,OTUB2 |
| phosphatidylinositol-3-phosphate binding | VPS36,KIF16B,WIPI2,D6WSU116E,ZFYVE26,RS1,SH3PXD2B,WDR45,PLEKHF1,SNX27 |
| superoxide-generating NADPH oxidase activator activity | AGT,NOXO1,PDGFB,NOXA1 |
| protein dimerization activity | OLIG4,POLR2J3,HES2.1,BHLHA15,USF1L,MYCH,AHR,NEUROD4,ATOH8,MNT |
Interacting Protein
NCF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCF4.
NCF2;NCF1;CYBA;MLH1;gatA
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