LTB

  • Official Full Name

    lymphotoxin beta (TNF superfamily, member 3)

  • Overview

    Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

  • Synonyms

    LTB;lymphotoxin beta (TNF superfamily, member 3);TNFC;lymphotoxin-beta;p33;TNFSF3;LT beta;lymphotoxin beta;tumor necrosis factor C;TNF-C;LT-beta;OTTHUMP00000029185;OTTHUMP00000215145;tumor necrosis factor ligand superfamily member 3

Recombinant Proteins

  • Cynomolgus
  • Rhesus macaque
  • Human
  • Mouse
  • Rat
  • Chimpanzee
  • Mus musculus
  • Insect Cell
  • Mammalian Cell
  • Human Cell
  • E.coli
  • HEK293
  • E.coli expression system
  • His
  • StrepII
  • His&Fc&Avi
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
LTB-1190C Recombinant Cynomolgus LTB Protein, His-tagged Insect Cell Cynomolgus His 49-244 a.a.
LTB-2590R Recombinant Rhesus monkey LTB Protein, His-tagged Mammalian Cell Rhesus macaque His
LTB-285H Recombinant Human LTB, StrepII-tagged Human Cell Human StrepII 49-244, 196 a.a.
Ltb-7122M Recombinant Mouse Ltb protein, His-tagged E.coli Mouse His Ile58~Met304
LTB-9344M Recombinant Mouse LTB Protein Mammalian Cell Mouse His
Ltb-1750R Recombinant Rat Ltb Protein, His-tagged E.coli Rat His Ala155-Val305
LTB-2410R Recombinant Rhesus Macaque LTB Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
LTB-2410R-B Recombinant Rhesus Macaque LTB Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
LTB-4588C Recombinant Chimpanzee LTB protein, His-tagged E.coli Chimpanzee His 49-244aa
LTB-4589C Recombinant Chimpanzee LTB protein, His-SUMO-tagged E.coli Chimpanzee His&SUMO 49-244aa
LTB-5235M Recombinant Mouse LTB Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
LTB-5235M-B Recombinant Mouse LTB Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL11585MF Recombinant Full Length Mouse Lymphotoxin-Beta(Ltb) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-306)

    Involved Pathway

    LTB involved in several pathways and played different roles in them. We selected most pathways LTB participated on our site, such as Cytokine-cytokine receptor interaction,NF-kappa B signaling pathway,Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rheumatoid arthritis ATP6V0B,GM-CSF,IL-8,ATP6V0A4,CD86,ATP6V0A1,TNFRSF11A,CCL5,ATP6V1F,ICAM1
    Cytokine-cytokine receptor interaction CCR3,IL17A,CLCF1,TGFB3,TNFSF10,CNTFR,CCL22,TNFRSF14,CRFB16,CSF2RB
    NF-kappa B signaling pathway BCL2L1,TICAM2,PLCG2,LAT,CCL4L1,GM10591,ERC1,ZAP70,RIPK1,BCL2

    Protein Function

    LTB has several biochemical functions, for example, cytokine activity,receptor binding,tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LTB itself. We selected most functions LTB had, and list some proteins which have the same functions with LTB. You can find most of the proteins on our site.

    Function Related Protein
    receptor binding TNFSF13,FGF11,UTS2,CD2,HTT,CXCL1,APLN,ANXA1,PTK6B,H2-Q10
    cytokine activity IL15,GRN,WNT2,IFNK,IL11,BMP8A,IL9,CMTM2,TNFSF4,Il1f8
    tumor necrosis factor receptor binding TRAF4,TNFSF4,TNFSF13B,CASP8,TRAF6,TRAF2,BRE,TRAP1,ERAP1,TRAF3

    Interacting Protein

    LTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTB here. Most of them are supplied by our site. Hope this information will be useful for your research of LTB.

    TNFSF14;galK;q7ch26_yerpe;isdC;rapA

    Resources

    Research Area

    B Cell CD Antigen
    Tumor Necrosis Factor (TNF)

    References

    • Qi, YL; Kang, HT; et al. Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the innmunogenicity of rabies virus-like particles in mice and dogs. FRONTIERS IN MICROBIOLOGY 6:-(2015).
    • Lei, H; Peng, XJ; et al. Intranasal Immunization with Live Recombinant Lactococcus lactis Combined with Heat-Labile Toxin B Subunit Protects Chickens from Highly Pathogenic Avian Influenza H5N1 Virus. JOURNAL OF MEDICAL VIROLOGY 87:39-44(2015).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All LTB Products

    Required fields are marked with *

    My Review for All LTB Products

    Required fields are marked with *