LSP1
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Official Full Name
lymphocyte-specific protein 1 -
Overview
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils,;macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and;transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
LSP1;lymphocyte-specific protein 1;WP34;52 kDa phosphoprotein;47 kDa actin binding protein;47 kDa actin-binding protein;leukocyte-specific protein 1;lymphocyte-specific antigen WP34;leufactin (leukocyte F-actin binding protein);F-actin binding an
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- HEK293T
- His
- Non
- His&T7
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
LSP1 involved in several pathways and played different roles in them. We selected most pathways LSP1 participated on our site, such as Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | C3,RAB5B,IL10RA,CALM1,FCGR3,RFXANK,RAB7,Itgam&Itgb2,HLA-DRB3,HLA-DRA |
Protein Function
LSP1 has several biochemical functions, for example, actin binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LSP1 itself. We selected most functions LSP1 had, and list some proteins which have the same functions with LSP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | TRHR2,PPFIA1,TRAF3,TAS2R118,GRM6B,OLFR478,MGAA,VMN1R52,OPRD1A,TAS2R117 |
| actin binding | MYH8,VMHCL,KLHL2,CAPGB,TPM3,CALD1,NF2,STK38L,HPCA,INPPL1B |
Interacting Protein
LSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LSP1.
LYPD3;SNAI1;IL24;SCGB2A2;GREB1;THRSP;KLK6
Resources
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References
- Hossain, M; Qadri, SM; et al. ICAM-1-mediated leukocyte adhesion is critical for the activation of endothelial LSP1. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 304:C895-C904(2013).
- Wu, Y; Zhan, LJ; et al. MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 358:170-175(2007).
