LPHN1
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Official Full Name
latrophilin 1 -
Overview
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms. -
Synonyms
LPHN1;latrophilin 1;latrophilin-1;CIRL1;KIAA0821;LEC2;Calcium independent alpha latrotoxin receptor 1;CL1;Latrophilin1;Lectomedin 2;LPHN 1;CIRL-1;lectomedin-2;calcium-independent alpha-latrotoxin receptor 1
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LPHN1-625H | Recombinant Human LPHN1, GST-tagged | E.coli | Human | GST | 1-201aa | |
| LPHN1-3440R | Recombinant Rat LPHN1 Protein | Mammalian Cell | Rat | His |
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| LPHN1-9200M | Recombinant Mouse LPHN1 Protein | Mammalian Cell | Mouse | His |
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| LPHN1-1029HCL | Recombinant Human LPHN1 cell lysate | Human | Non |
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| LPHN1-2402H | Recombinant Human LPHN1 Protein, His-tagged | E.coli | Human | His | Val248-Val390 |
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| LPHN1-3096R | Recombinant Rat LPHN1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| LPHN1-3096R-B | Recombinant Rat LPHN1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| LPHN1-4719H | Recombinant Human LPHN1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| LPHN1-4720H | Recombinant Human LPHN1 Protein | Wheat Germ | Human | Non |
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| LPHN1-5140M | Recombinant Mouse LPHN1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LPHN1-5140M-B | Recombinant Mouse LPHN1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| LPHN1-5988HF | Recombinant Full Length Human LPHN1 Protein | In Vitro Cell Free System | Human | Full L. 343 amino acids |
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| LPHN1-5990HF | Recombinant Full Length Human LPHN1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 201 amino acids |
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Involved Pathway
LPHN1 involved in several pathways and played different roles in them. We selected most pathways LPHN1 participated on our site, such as GPCRs, Class B Secretin-like, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPHN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Class B Secretin-like | EMR1,EMR2,CRHR2,CALCRL,CD97,CRHR1,ADCYAP1R1,ELTD1 |
Protein Function
LPHN1 has several biochemical functions, for example, G-protein coupled receptor activity,carbohydrate binding,cell adhesion molecule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPHN1 itself. We selected most functions LPHN1 had, and list some proteins which have the same functions with LPHN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesion molecule binding | NRXN1,CPE,PTPRD,PTBP3,ITGAL,CADM3,ADAM8,NLGN4X,TENM2,DSP |
| carbohydrate binding | ATRN,MAN2A1,FCNA,EMC7,GALNT9,SIGLEC14,GALNT14,LGALS9L1,MLEC,PKD1 |
| protein binding | LUM,RFC5,DCLRE1C,KCNA3,CACNB2,MCL1,EIF1AX,CC2D2A,CASK,TXLNA |
| G-protein coupled receptor activity | VMN1R45,RRH,GRM3,CHRM5B,ADRA2DB,GPR37B,APLNRA,CELSR1,OLFR150,CMKLR1 |
Interacting Protein
LPHN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPHN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPHN1.
CACNA1A;APC
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References
- Davydov, II; Fidalgo, S; et al. Prediction of Epitopes in Closely Related Proteins Using a New Algorithm. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 148:869-873(2009).
- Harder, A; Schmitt-Wrede, HP; et al. Cyclooctadepsipeptides - an anthelmintically active class of compounds exhibiting a novel mode of action. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 22:318-331(2003).
