LILRB1
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Official Full Name
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 -
Overview
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LILRB1;leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1;leukocyte immunoglobulin-like receptor subfamily B member 1;CD85;CD85j;ILT2;LIR 1;LIR1;MIR 7;ILT-2;CD85 antigen;Ig-like transcript 2;leukocyte Ig-like receptor-1;immunoglobulin-like transcript 2;CD85 antigen-like family member J;leukocyte immunoglobulin-like receptor 1;monocyte/macrophage immunoglobulin-like receptor 7;leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform;MIR7;LIR-1;MIR-7;FLJ37515
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- E.coli
- C-His
- HEK293
- Human Cell
- Insect cells
- Human Cells
- Human cells
- Mammalian cells
- HEK293T
- His
- Fc
- mFc
- Fc&Avi
- Non
- hIgG4
- His&T7
- His&Avi
- C-His&Flag
- Myc&DDK
Involved Pathway
LILRB1 involved in several pathways and played different roles in them. We selected most pathways LILRB1 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | SLAMF6,AMICA1,CD96,CD300C,CD300LF,PVRL2L,SIGLEC6,LILRA1,LILRB4,SIGLEC11 |
| Osteoclast differentiation | SIRPG,FCGR2C,NOX1,GAB2,MAPK9,MAPK1,FOSL2,PIK3CB,LILRA1,CYBA |
| Adaptive Immune System | CD300A,AP1G1,NRG4,FGF8B,KIF26A,LRSAM1,OSCAR,TRAT1,LILRA2,ASB13 |
| Immune System | SIGLEC11,CD300E,GBP1,SH3RF1,MAP3K8,CLEC2B,RAPGEF4,KIF11,KIF26A,ABI1B |
Protein Function
LILRB1 has several biochemical functions, for example, HLA-A specific inhibitory MHC class I receptor activity,HLA-B specific inhibitory MHC class I receptor activity,MHC class I protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LILRB1 itself. We selected most functions LILRB1 had, and list some proteins which have the same functions with LILRB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| HLA-B specific inhibitory MHC class I receptor activity | KIR3DL1 |
| MHC class I protein binding | VCP,Pilrb1,HLA-E,PILRB2,TUBB,TAPBP,CD8A,DERL1,TAP1,LILRB2 |
| protein homodimerization activity | PDZD7,DHDPSL,PVRL1,PYGB,USH1G,HSPB6,ERCC5,PGCP,ANXA6,QPRT |
| MHC class I receptor activity | KLRF1,MR1,KIR3DS1,CD160 |
| protein phosphatase 1 binding | PHACTR3A,SH3RF2,TCTEX1D4,PPP1R15A,PHACTR4B,PHACTR3,FER,PHACTR1,PAWR,SHOC2 |
| SH2 domain binding | SKAP1,INPPL1,LCK,ARHGAP5,CTR9,TRPV4,LAT2,SIT1,SHCBP1,IRS1 |
Interacting Protein
LILRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRB1.
CSK;HLA-G;uup;q81vw1_bacan
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesCo-stimulatory ILT/CD85 Family Proteins
MHC Class I
MHC Class II
T Cell Antigen Recognition
Co-stimulatory Molecules
Macrophage Markers
Monocyte Markers
Other Proteins Involved in Regulating B Cell Activation
Thymus-Independent B Cell Activation
Dendritic Cell ITIM/ITAM Immunoreceptors
Dendritic Cell Pathogen Recognition/Uptake
Related Services
Related Products
References
- Chan, KR; Ong, EZ; et al. Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:2722-2727(2014).
- Li, NL; Fu, L; et al. Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18. EUROPEAN JOURNAL OF IMMUNOLOGY 43:1042-1052(2013).
