LIG1
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Official Full Name
ligase I, DNA, ATP-dependent -
Overview
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process.Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. -
Synonyms
LIG1;ligase I, DNA, ATP-dependent;DNA ligase 1;polydeoxyribonucleotide synthase [ATP] 1;MGC117397;MGC130025
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- His
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
- Flag
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LIG1-3849H | Recombinant Human LIG1 protein, His-tagged | E.coli | Human | His | 670-919 aa | |
| LIG1-1519H | Recombinant Human LIG1 protein | E.coli | Human | Non |
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| LIG1-26930TH | Recombinant Human LIG1, His-tagged | E.coli | Human | His | 484-919 a.a. |
|
| Lig1-6751R | Recombinant Rat Lig1 protein, His & T7-tagged | E.coli | Rat | His&T7 | Lys568~Phe875 |
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| LIG1-985HCL | Recombinant Human LIG1 cell lysate | Human | Non |
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| LIG1-1293H | Recombinant Human LIG1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| LIG1-1293H-B | Recombinant Human LIG1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Lig1-1318M | Recombinant Mouse Lig1 Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| LIG1-196HFL | Active Recombinant Full Length Human LIG1 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| LIG1-3175H | Recombinant Human LIG1 protein, GST-tagged | E.coli | Human | GST | 1-919aa |
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| LIG1-4446H | Recombinant Human LIG1 Protein (Gly484-Ile663), N-His tagged | E.coli | Human | His | Gly484-Ile663 |
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Involved Pathway
LIG1 involved in several pathways and played different roles in them. We selected most pathways LIG1 participated on our site, such as DNA replication,Base excision repair,Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | mutY,HMGB1B,POLD3,HMGB1,NEIL2,HMGB1A,PARP4,PNKP,POLD1,TDG |
| DNA Replication | rnhA,PRIM2,GINS2,GMNN,CDT1,POLA2,MCM6L,PCNA,SSBP1,RFC3 |
| Nucleotide Excision Repair | COPS7A,MCRS1,INO80B,COPS2,GTF2H5,GTF2H1,ZFP830,RFC4,CCNH,RFC5 |
| Mismatch repair | RFC1,RFC3,MSH6,PCNA,POLD2,RPA4,MSH2,RFC5,RPA1,MLH3 |
Protein Function
LIG1 has several biochemical functions, for example, ATP binding,DNA binding,DNA ligase (ATP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIG1 itself. We selected most functions LIG1 had, and list some proteins which have the same functions with LIG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | TAX1BP1B,ASAP2,HE2,ANTXR1,ZBTB25,MGAT5B,CXXC1A,GNPTAB,COL5A2,TYRP1B |
| ATP binding | NSFB,RPS6KB2,SUCLG1,RPS6KA1,OXSR1B,NLRP4,CAMKK1B,SYN1,SMG1,FAM20B |
| DNA ligase (ATP) activity | LIG3,LIG4 |
| DNA binding | XBP1,IRF2,EME1,NKX2.3,E2F6,SPI1B,ZNF823,TGIF2LX,SUPT3H,ZFP191 |
| DNA ligase activity | LIG3,LIG4 |
Interacting Protein
LIG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIG1.
TUBB4A;HSPB1;RGS2;INPP1;Lyplal1;AURKA;Tgs1
Resources
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References
- Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).
- Cordoba-Canero, D; Roldan-Arjona, T; et al. Arabidopsis ARP endonuclease functions in a branched base excision DNA repair pathway completed by LIG1. PLANT JOURNAL 68:693-702(2011).
