LGALS3BP
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Official Full Name
lectin, galactoside-binding, soluble, 3 binding protein -
Overview
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. -
Synonyms
LGALS3BP;lectin, galactoside-binding, soluble, 3 binding protein;galectin-3-binding protein;90K;BTBD17B;L3 antigen;Mac 2 binding protein;MAC 2 BP;serum protein 90K;MAC2BP;Tumor associated antigen 90K;90K MAC 2 BP;Basement membrane autoantigen p105;Galectin 3 binding protein;Lectin galactoside binding soluble 3 binding protein;Lectin galactoside-binding soluble 3-binding protein;LG3BP_HUMAN;M2BP;Mac-2 BP;Mac-2-binding protein;Tumor-associated antigen 90K;MAC-2-BP
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian cells
- E.coli
- Mammalian Cell
- HEK293
- His
- T7
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
LGALS3BP involved in several pathways and played different roles in them. We selected most pathways LGALS3BP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LGALS3BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LGALS3BP has several biochemical functions, for example, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LGALS3BP itself. We selected most functions LGALS3BP had, and list some proteins which have the same functions with LGALS3BP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| scavenger receptor activity | CD5L,TMPRSS4B,TMPRSS3,PRG4B,LOXL3A,SCARA3,CCBP2,SCARF2,TMPRSS13B,CD163 |
Interacting Protein
LGALS3BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGALS3BP here. Most of them are supplied by our site. Hope this information will be useful for your research of LGALS3BP.
Tubg1;Nup107;Mzt2;gag-pol;NFKB2;HSP90AB1;MAP3K8;Cbx1;RELA;MAP3K1;IKBKE;TRADD;Mzt1;Gorasp1
Resources
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References
- Stampolidis, P; Ullrich, A; et al. LGALS3BP, lectin galactoside-binding soluble 3 binding protein, promotes oncogenic cellular events impeded by antibody intervention. ONCOGENE 34:39-52(2015).
- Traini, S; Piccolo, E; et al. Inhibition of Tumor Growth and Angiogenesis by SP-2, an Anti-Lectin, Galactoside-Binding Soluble 3 Binding Protein (LGALS3BP) Antibody. MOLECULAR CANCER THERAPEUTICS 13:916-925(2014).
