LFNG
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Official Full Name
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -
Overview
This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LFNG;LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;lunatic fringe (Drosophila) homolog , lunatic fringe homolog (Drosophila);beta-1,3-N-acetylglucosaminyltransferase lunatic fringe;SCDO3;3-N-acetylglucosaminyltransferase lunatic fringe;Beta-1;Beta-13-N-acetylglucosaminyltransferase lunatic fringe;LFNG_HUMAN;O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;OTTHUMP00000201070;OTTHUMP00000201071;OTTHUMP00000201072;OTTHUMP00000201073
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mus musculus
- Wheat Germ
- Mammalian Cell
- E.coli
- In Vitro Cell Free System
- HEK293
- E.coli expression system
- Non
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LFNG-29854TH | Recombinant Human LFNG | Wheat Germ | Human | Non | 250 amino acids |
|
| LFNG-3384R | Recombinant Rat LFNG Protein | Mammalian Cell | Rat | His |
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| LFNG-6508C | Recombinant Chicken LFNG | Mammalian Cell | Chicken | His |
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| LFNG-8607Z | Recombinant Zebrafish LFNG | Mammalian Cell | Zebrafish | His |
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| LFNG-983HCL | Recombinant Human LFNG cell lysate | Human | Non |
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| LFNG-2140H | Recombinant Human LFNG Protein (1-250 aa), GST-tagged | E.coli | Human | GST | 1-250 aa |
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| LFNG-286HF | Recombinant Full Length Human LFNG Protein | In Vitro Cell Free System | Human | Full L. 250 amino acids |
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| LFNG-3040R | Recombinant Rat LFNG Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| LFNG-3040R-B | Recombinant Rat LFNG Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RFL4497GF | Recombinant Full Length Chicken Beta-1,3-N-Acetylglucosaminyltransferase Lunatic Fringe(Lfng) Protein, His-Tagged | E.coli expression system | Chicken | His | Full L. Full Length (1-363) |
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| RFL9829MF | Recombinant Full Length Mouse Beta-1,3-N-Acetylglucosaminyltransferase Lunatic Fringe(Lfng) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-378) |
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Involved Pathway
LFNG involved in several pathways and played different roles in them. We selected most pathways LFNG participated on our site, such as Other types of O-glycan biosynthesis,Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LFNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other types of O-glycan biosynthesis | FUT4,B3GALTLB,B3GAT1,POGLUT1,POMT1,POFUT1,B3GALTL,GXYLT1B,COLGALT2,FUT9 |
| Notch signaling pathway | DLK1,CTBP2A,NOTCH3,NUMB,DVL3A,CTBP2,HDAC1,HER15.1,DNER,DLB |
Protein Function
LFNG has several biochemical functions, for example, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity,metal ion binding,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by LFNG itself. We selected most functions LFNG had, and list some proteins which have the same functions with LFNG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | TAGAP1,ASF1BB,CRYGM2F,VMN1R139,ARRDC3A,GM4305,CSMD1A,RNFT1,VWA5B2,ZNF688 |
| metal ion binding | MSS51,CACNA2D1,PLD6,POLH,E4F1,PDE6B,MAP2K2,REPIN1,ZFP488,DMPK |
| O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity | RFNG,MFNG |
Interacting Protein
LFNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LFNG here. Most of them are supplied by our site. Hope this information will be useful for your research of LFNG.
LFNG Related Signal Pathway
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References
