LAT
-
Official Full Name
linker for activation of T cells -
Overview
Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosine- phosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (#132, #171, #191 and #226 in human LAT) are cru -
Synonyms
LAT;linker for activation of T cells;linker for activation of T-cells family member 1;LAT1;transmembrane adaptor;p36-38;36 kDa phospho-tyrosine adapter protein;36 kDa phospho-tyrosine adaptor protein;linker for activation of T cells, transmembrane adaptor;pp36
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Mus musculus
- E. coli
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
LAT involved in several pathways and played different roles in them. We selected most pathways LAT participated on our site, such as Ras signaling pathway,Rap signaling pathway,NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fc gamma R-mediated phagocytosis | MARCKS,FCGR3A,SPHK2,PLCG1,FCGR1A,HCK,PRKCB,DOCK2,LIMK2,MAPK1 |
| T cell receptor signaling pathway | CD8B,CABIN1,CBLC,DEF6A,CBLB,IKBKG,CD40LG,PPP3CC,RAF1,NFKB1 |
| NF-kappa B signaling pathway | PLAU,Bcl2a1b,XIAP,BIRC3,CXCL2,TLR4,LTB,MAP3K7IP3,LYN,PLCG1 |
| Ras signaling pathway | GNG5,PRKACB,MET,PLCE1,ANGPT2,INS1,FASLG,RAB5C,HGF,RAB5B |
| Natural killer cell mediated cytotoxicity | NCR3,SAMD3,KIR2DS5,SHC4,ZAP70,KLRD1,RAET1L,IFNA12,SH3BP2,KLRK1 |
| Fc epsilon RI signaling pathway | MAPK13,FCER1G,MAP2K6,PIK3R5,VAV2,PIK3R1,MAP2K3,AKT1,RAC1,MS4A2 |
| Rap signaling pathway | RALGDS,PIK3R1,LPAR4,FGF10,CALM1,SKAP1,KRAS,KLK1B4,MAPK13,RAP1B |
Protein Function
LAT has several biochemical functions, for example, SH3/SH2 adaptor activity,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAT itself. We selected most functions LAT had, and list some proteins which have the same functions with LAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | SQSTM1,KCNQ3,GOLGA2,CCNK,ADIPOR1,CHRNA7,THY1,TBC1D14,MAP3K2,TUBB3 |
| protein binding | GNG12,TCEB3,CAPNS2,FUT11,HIST1H4E,GATA1A,SMCO3,SF3A2,FRK,FGA |
| SH3/SH2 adaptor activity | CRK,GRB2,RUSC1,TOB1,SH2D3A,EPS8,HSH2D,CHN2,GRB10,ARHGAP1 |
Interacting Protein
LAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LAT.
GRB2;PLCG1;PTPN1
Resources
Related Services
Related Products
References
- Finch, ML; Passman, AM; et al. Sub-Cellular Localisation Studies May Spuriously Detect the Yes-Associated Protein, YAP, in Nucleoli Leading to Potentially Invalid Conclusions of Its Function. PLOS ONE 10:-(2015).
- Du, T; Han, ZY; et al. Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E49-E55(2015).
