KLKB1
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Official Full Name
kallikrein B, plasma (Fletcher factor) 1 -
Overview
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008] -
Synonyms
KLKB1;kallikrein B, plasma (Fletcher factor) 1;PPK;KLK3;plasma kallikrein;kininogenin;Fletcher factor;plasma prekallikrein;plasma kallikrein heavy chain;plasma kallikrein light chain
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Pig
- Rat
- Mammalian cells
- C-His
- Human Urine
- Porcine (pig) Pancreas
- E.coli
- Yeast
- HEK293
- Mammalian Cell
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
KLKB1 involved in several pathways and played different roles in them. We selected most pathways KLKB1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C9,PROC,C3,C1R,SERPINA5,Serpina1c,C5,PROS1,PLAT,SERPINA1E |
Protein Function
KLKB1 has several biochemical functions, for example, protein binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLKB1 itself. We selected most functions KLKB1 had, and list some proteins which have the same functions with KLKB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | KLK8,MCPT8,HTRA1,GM5077,PLAUB,PLG,KLK10,PRSS2,CFI,TMPRSS7 |
| protein binding | ETS2,CYCS,ERAP1,AMIGO2,DYNLT3,RPS19BP1,RFPL4,LTBP1,MESDC1,SERPINE2 |
Interacting Protein
KLKB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLKB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLKB1.
Resources
Research Area
Serine Proteases and RegulatorsKinin System
Coagulation Cascade Proteases
Plasmin/Plasminogen and Kallikrein/Kinin Systems
Related Services
Related Products
References
