KLF4
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Official Full Name
Kruppel-like factor 4 (gut) -
Overview
Krueppel-like factor 4 is a protein that in humans is encoded by the KLF4 gene.. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSC -
Synonyms
KLF4;Kruppel-like factor 4 (gut);Krueppel-like factor 4;EZF;GKLF;gut-enriched krueppel-like factor;epithelial zinc finger protein EZF;endothelial Kruppel-like zinc finger protein
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- HEK293T
- Mammalian cells
- Non
- TAT
- His
- His&CaM
- His&T7
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
KLF4 involved in several pathways and played different roles in them. We selected most pathways KLF4 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | SKIL,FZD5,LIFR,FZD6,REST,FGF2,WNT7B,PIK3CD,PIK3R2,RAF1 |
Protein Function
KLF4 has several biochemical functions, for example, RNA polymerase II transcription factor binding,beta-catenin binding,core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF4 itself. We selected most functions KLF4 had, and list some proteins which have the same functions with KLF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| core promoter proximal region sequence-specific DNA binding | SP3A,DMRT3A,DMRTC2,DMRT1,DMRT2B,UHRF1,GATA3,DMRTC1C2,SP3,DMRTA2 |
| protein binding | SKP1,PIANP,SLC26A6,DGKZ,GJD3,NCBP2,NSL1,PEX11B,SPTSSA,HPRT1 |
| histone deacetylase binding | BCOR,PRDM1,ANKRD1,YWHAB,SRF,MEF2B,RAD9,XBP1,MAGEA2B,SFPQ |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | CEBPG,TP73,Ar,CREB3L2,NRL,NOBOX,NR4A1,DDIT3,ZFAT,ARNT2 |
| zinc ion binding | ZRANB2,MUL1,MT1X,MORC2A,ADAM5P,MEP1A,ADAM19,KDM5A,NEURL1B,Car2 |
| transcription cofactor binding | TRP53,CHD6,FOXO3 |
| transcription regulatory region DNA binding | RFX6,GABPB2,SNCA,SERPINB1A,NFE2L2,SIX1,TBL1XR1,TA,ZFP161,SALL2 |
| beta-catenin binding | APC2,BCL9,SMAD7,DVL3,TCF7L2,TCF7,APC,CDH2,PTPRJ,TAX1BP3 |
| core promoter binding | CCAR1,ARNTL,GADD45A,E2F7,HDAC1,EZH2,PYDC3,TFAP2C,ELK4,HDAC6 |
Interacting Protein
KLF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF4.
cd14_distal_promoter_probe;CTBP1;Dlg4
Resources
Research Area
Endothelial Cell MarkersTranscription Regulators in Endothelial Cells
Transcription Regulators in VSMC
Cancer Stem Cell Transcription Factors
Neural Stem Cell Transcription Factors
Embryonic and Induced Pluripotent Stem Cell Markers
Epithelial Cell Markers and Intracellular Molecules
Pluripotent Stem Cell Transcription Factors
Related Services
Related Products
References
- Shimamoto, R; Amano, N; et al. Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice. PLOS ONE 9:-(2014).
- Makanga, JO; Kobayashi, M; et al. Generation of Rat Induced Pluripotent Stem Cells Using a Plasmid Vector and Possible Application of a Keratan Sulfate Glycan Recognizing Antibody in Discriminating Teratoma Formation Phenotypes. BIOLOGICAL & PHARMACEUTICAL BULLETIN 38:127-133(2015).
