KLB
-
Official Full Name
klotho beta -
Synonyms
KLB;klotho beta;beta-klotho;betaKlotho;klotho beta like;klotho beta-like protein;BKL;MGC142213
Recombinant Proteins
- Human
- Mouse
- Monkey
- Rat
- Rhesus macaque
- Mammalian cells
- NS0
- HEK293
- Mammalian Cell
- E.coli
- His
- Fc
- His&Fc&Avi
Involved Pathway
KLB involved in several pathways and played different roles in them. We selected most pathways KLB participated on our site, such as ARMS-mediated activation,Adaptive Immune System,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 signaling | FRS2,IL17RD,AGO3,RASGEF1A,CSF2RA,DUSP10,PTPRA,DUSP5,KBTBD7,PAQR3B |
| DAP12 interactions | GRAP2B,TRAT1,CSF2RB,AGO2,JAK1,SPTB,PEA15A,DAB2IPB,PRKAR1AA,DUSP4 |
| Adaptive Immune System | ASB8,CLEC2D,TRIM9,CLEC2B,IGHM,TPP2,UBE2L6,CD200,PVRL2L,KLHL20 |
| Constitutive Signaling by Aberrant PI3K in Cancer | EGF,TRAT1,FRS2,NRG4,NRG3,HBEGF |
| ARMS-mediated activation | DUSP2,CRK,CSF2RB,SPRED3,IL17RD,SPNA2,DUSP10,RASGRP4,FRS2A,DUSP6 |
| Axon guidance | SEMA6B,EFNA2,DNM1,SCN2A,DUSP1,CDK5,DAB2IPB,ACTR2,NTN1A,L1CAM |
| Cytokine Signaling in Immune system | IFIT2,TRIM38,PELI1,PRLRB,TRIM46,TRIM2,PAQR3B,NRG2A,XAF1,TRIM17 |
| Developmental Biology | SEMA3AB,WDR83,COL4A5,LGI4,ACTR2,GPC1B,EPHB3A,RGMA,DUSP10,AP2B1 |
Protein Function
KLB has several biochemical functions, for example, fibroblast growth factor binding,fibroblast growth factor receptor binding,hydrolase activity, hydrolyzing O-glycosyl compounds. Some of the functions are cooperated with other proteins, some of the functions could acted by KLB itself. We selected most functions KLB had, and list some proteins which have the same functions with KLB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity, hydrolyzing O-glycosyl compounds | ABHD10,KIAA1161,LCTLB,GBE1,CHIA.3,GNE,LCTLA,CHIA.1,CHIA.2,Chil3 |
| protein binding | TNK2,THOC7,MTX2,LLGL2,MAP3K2,FBXL14,KIR2DL3,DLGAP1,TIPRL,GRN |
| fibroblast growth factor receptor binding | FGF8,FGF18B,Fgf15,FGF20,FGF10A,FGF6,FGF10B,FRS2,FGF8B,FGF2 |
| fibroblast growth factor binding | FIBP,FGFR4,FIBPA,Api5,RPS19,FGFBP3,GLG1,FGFR1A,FIBPB,FGFRL1 |
Interacting Protein
KLB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLB here. Most of them are supplied by our site. Hope this information will be useful for your research of KLB.
FGFR1;FGF21;midostaurin
Resources
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References
- Almilaji, A; Pakladok, T; et al. Upregulation of KCNQ1/KCNE1 K+ channels by Klotho. CHANNELS 8:-(2014).
- Zhang, J; Li, Y; et al. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. DRUG DISCOVERY TODAY 19:579-589(2014).
