KIR2DS1
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Official Full Name
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 -
Overview
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. -
Synonyms
KIR2DS1;killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1;killer cell immunoglobulin-like receptor 2DS1;CD158H;EB6ActI;EB6ActII;p50.1;CD158 antigen-like family member H;CD158a;KI2S1_HUMAN;MHC class I NK cell receptor Eb6 ActI;XXbac-BCX195L8.7;KIR2DL1-KIR2DS1;killer-cell immunoglobulin-like receptor;killer cell immunoglobulin-like receptor KIRDS1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KIR2DS1-1014H | Recombinant Human KIR2DS1 Protein (22-245 aa), His-tagged | E.coli | Human | His | 22-245 aa |
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| KIR2DS1-1663H | Recombinant Human KIR2DS1 Protein (22-245 aa), His-tagged | Yeast | Human | His | 22-245 aa |
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Involved Pathway
KIR2DS1 involved in several pathways and played different roles in them. We selected most pathways KIR2DS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
KIR2DS1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DS1 itself. We selected most functions KIR2DS1 had, and list some proteins which have the same functions with KIR2DS1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
KIR2DS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DS1.
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References
- Czaja, K; Borer, AS; et al. A comprehensive analysis of the binding of anti-MR antibodies to activating KIRs. GENES AND IMMUNITY 15:33-37(2014).
- Hervier, B; Beziat, V; et al. Phenotype and Function of Natural Killer Cells in Systemic Lupus Erythematosus. ARTHRITIS AND RHEUMATISM 63:1698-1706(2011).
