KDM4C
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Official Full Name
lysine (K)-specific demethylase 4C -
Overview
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] -
Synonyms
KDM4C;lysine (K)-specific demethylase 4C;GASC1;JHDM3C;JMJD2C;TDRD14C;bA146B14.1;lysine-specific demethylase 4C;GASC-1 protein;tudor domain containing 14C;jumonji domain containing 2C;jumonji domain-containing protein 2C;gene amplified in squamous cell carcinoma 1 protein;JmjC domain-containing histone demethylation protein 3C
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- His
- Flag
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
KDM4C involved in several pathways and played different roles in them. We selected most pathways KDM4C participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3,Chromatin modifying enzymes,Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM4C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDMs demethylate histones | KDM1B,ARID5B,KDM2B,KDM5D,KDM5B,JMJD6,KDM5BB,KDM4B,KDM5BA,KDM6AL |
| Chromatin organization | KDM4A,MBD3A,ASH2L,CHD4,ING3,SUZ12A,MSL1A,ELP4,SMARCB1,KDM5D |
| Coregulation of Androgen receptor activity | PIAS3,TCF4,PAWR,KDM3A,PA2G4,CMTM2,PATZ1,SNURF,CTDSP2,CMTM2A |
| RHO GTPase Effectors | NCKAP1,KNTC1,RCC2,SGOL2,FMNL1,IQGAP3,RHOAE,TAX1BP3,NOXO1,NUF2 |
| Chromatin modifying enzymes | BRPF1,PHF17,MORF4L1,PAX3A,MEAF6,KAT6B,ANO9A,ING5A,CAPNS2,PHF2 |
| Signal Transduction | SHARPIN,PPY,AXL,PCSK6,ARHGAP33,CHRDL1,HCAR1-2,CIT,FAM105B,RSPO3 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | NCOA2,HIST3H2BB,HIST4H4,HIST2H3C,KDM1A |
Protein Function
KDM4C has several biochemical functions, for example, androgen receptor binding,dioxygenase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM4C itself. We selected most functions KDM4C had, and list some proteins which have the same functions with KDM4C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dioxygenase activity | LEPREL1,ALOX8,PLOD1A,PTGS2,ALOX12E,TDO2A,BCO2L,PHYHD1,KDM3B,ALOX5A |
| histone demethylase activity | PHF8,KDM1A,KDM2B |
| zinc ion binding | ENPEP,LHX1B,PGLYRP6,NR4A2B,CIZ1,KLF7,HNF4A,LNPEP,ADAMTS15A,NANOS1 |
| histone demethylase activity (H3-K9 specific) | KDM7AB,KDM4D,PHF2,PHF8,KDM1A,JHDM1D |
| enzyme binding | IQCB1,RCOR2,GSTM3,CYP2A4,ATXN10,MAPK8,H2AFX,HDAC6,ATP6AP2,PICK1 |
| androgen receptor binding | RNF14,PARK7,EP300,BRCA1,RNF6,CALR,SMARCA4,NCOA1,FOXH1,RNF4 |
Interacting Protein
KDM4C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM4C here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM4C.
CBX4;rbl1_human_gene;orc1_human_gene;cdc6_human_gene;msh2_human_gene;dpola_human_gene;ccne1_human_gene;mcm3_human_gene;pcna_human_gene;ccnb1_human_gene;mpip1_human_gene;dyr_human_gene
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References
- Chin, YW; Han, SY; et al. KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review. EXPERT OPINION ON THERAPEUTIC PATENTS 25:135-144(2015).
- Guo, XQ; Tian, ZT; et al. Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2 alpha. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47:106-113(2015).
