KCNJ12
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Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 12 -
Overview
This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] -
Synonyms
KCNJ12;potassium inwardly-rectifying channel, subfamily J, member 12;IRK2;hIRK;IRK-2;hIRK1;KCNJN1;Kir2.2;Kir2.2v;kcnj12x;hkir2.2x;ATP-sensitive inward rectifier potassium channel 12;inward rectifier K(+) channel Kir2.2;inward rectifier K(+) channel Kir2.6;inward rectifier K(+) channel Kir2.2v;potassium channel, inwardly rectifying subfamily J member 12;potassium inwardly-rectifying channel, subfamily J, inhibitor 1
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- Bovine
- E.coli
- E.Coli or Yeast
- Mammalian Cell
- HEK293
- E.coli expression system
- GST
- His
- His&Fc&Avi
Involved Pathway
KCNJ12 involved in several pathways and played different roles in them. We selected most pathways KCNJ12 participated on our site, such as Activation of G protein gated Potassium channels,Activation of GABAB receptors,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GABA receptor activation | KCNJ2,GNB3A,KCNJ2A,ARHGEF9,GNGT2B,GNGT2A,KCNJ9,KCNJ10,KCNJ4,KCNJ15 |
| G protein gated Potassium channels | KCNJ6,GNB3A,GNB3B,GNGT2A,GNGT2B,KCNJ2A,KCNJ5,KCNJ9,KCNJ4,KCNJ10 |
| Cholinergic synapse | ITPR3,CHRNA4,GNG10,PRKACB,KCNQ5,GNG8,CREB3L4,CHAT,AKR1C1,PLCB2 |
| Activation of GABAB receptors | KCNJ6,GNB3A,KCNJ10,GNGT2B,ADCY3,ADCY1,KCNJ4,GNGT2A,ADCY7,KCNJ3 |
| Activation of G protein gated Potassium channels | GNGT2B,KCNJ15,KCNJ2A,KCNJ10,GNB3A,KCNJ5,KCNJ3,KCNJ4,GNGT2A,KCNJ6 |
| GABA B receptor activation | KCNJ2A,KCNJ5,KCNJ9,KCNJ15,GNB3A,KCNJ6,GNGT2A,KCNJ10,KCNJ2,KCNJ4 |
| Classical Kir channels | KCNJ2,KCNJ4,KCNJ14,KCNJ2A |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | KCNJ4,KCNJ10,GNGT2A,KCNJ2A,GNGT2B,KCNJ15 |
Protein Function
KCNJ12 has several biochemical functions, for example, inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ12 itself. We selected most functions KCNJ12 had, and list some proteins which have the same functions with KCNJ12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inward rectifier potassium channel activity | KCNJ1A.2,KCNJ16,KCNJ14,KCNJ1A.5,KCNJ18,KCNJ11L,KCNJ15,KCNJ2A,KCNJ13,KCNK6 |
Interacting Protein
KCNJ12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ12 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ12.
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References
- Zhu, XZ; Liang, J; et al. Calcium Intake and Ion Transporter Genetic Polymorphisms Interact in Human Colorectal Neoplasia Risk in a 2-Phase Study. JOURNAL OF NUTRITION 144:1734-1741(2014).
- Li, Q; Chen, M; et al. KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41:748-754(2014).
