KCNIP3
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Official Full Name
Kv channel interacting protein 3, calsenilin -
Overview
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
KCNIP3;Kv channel interacting protein 3, calsenilin;calsenilin, presenilin binding protein, EF hand transcription factor , CSEN;calsenilin;DREAM;KCHIP3;DRE-antagonist modulator;kv channel-interacting protein 3;potassium channel interacting protein
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- E. coli
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
KCNIP3 involved in several pathways and played different roles in them. We selected most pathways KCNIP3 participated on our site, such as IL-3 Signaling Pathway,TSH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNIP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL-3 Signaling Pathway | GNB2L1,CISH,GATA2,BMX,GATA1A,BIRC5A,PILRB,GATA1,GATA2A,SPI1B |
Protein Function
KCNIP3 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNIP3 itself. We selected most functions KCNIP3 had, and list some proteins which have the same functions with KCNIP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium channel regulator activity | ARPP19,KCNMB3,KCNS3,SGK1,PIAS3,KCNIP1,KCNIP2,KCNAB2,DPP6,ADRB2 |
| potassium channel activity | KCNH6A,TRPM5,KCNQ3,KCNK3A,TMEM38B,KCNA2B,FXYD4,DDX1,KCNV2,KCNK16 |
| transcription corepressor activity | KCTD1,RUNX1T1,TOB1,SP100,ASXL1,PIAS1,ZMYND11,SOD3,CDX2,LHX1 |
| protein binding | DHX32,ZNF643,ZNF398,HSPA6,MYO5B,PRSS8,MLANA,SIRT1,UCP3,ECT2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | EN1,NR1H2,POU3F2,ONECUT2,POU4F2,MAX,PDX1,TCF3,ARNT2,KDM6A |
| DNA binding | ZNF184,HIST1H3D,MSGN1,HIST1H2BD,GTF2IRD1,MSH4,POU4F1,NKX3.3,POLR2L,FOXF2A |
| calcium-dependent protein binding | CHP1,SELP,CALM1,ANXA11,CD209A,DMBT1,S100A11,DDX5,ALG2,SYN1 |
| calcium ion binding | THBS4A,CAPN3,HMCN1,PLSCR3,CRB2B,OCM2,GUCA1E,MASP1,PCDHA8,EFHD2 |
| protein C-terminus binding | ERCC2,SCLT1,LIG4,PEX5,SIAH1,PIAS4,HIC2,SDC1,RAD51,PHB2 |
Interacting Protein
KCNIP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNIP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNIP3.
CD177;28793;IGF1R;IL6ST;MAVS
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