KAT2A

  • Official Full Name

    K(lysine) acetyltransferase 2A

  • Overview

    KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also;functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA;(MIM 164014) in a HAT-independent manner (Mao et al., 2009 (PubMed 19339690)).

  • Synonyms

    KAT2A;K(lysine) acetyltransferase 2A;GCN5 general control of amino acid synthesis 5 like 2 (yeast) , GCN5L2;histone acetyltransferase KAT2A;GCN5;PCAF b;STAF97;hsGCN5;lysine acetyltransferase 2A;histone acetyltransferase GCN5;general control of a

Recombinant Proteins

  • Human
  • Sf9 Cells
  • Sf21 Cells
  • Human
  • E.coli
  • Insect Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
KAT2A-1392H Active Recombinant Human KAT2A, GST-tagged Sf9 Cells Human GST 323 aa-end
KAT2A-274H Active Recombinant Human KAT2A, His-tagged Sf21 Cells Human His
KAT2A-1017H Recombinant Human KAT2A, His-tagged Human Human His
KAT2A-120H Recombinant Human KAT2A Protein, GST-tagged E.coli Human GST 726-837
KAT2A-18H Recombinant Human KAT2A Protein, GST-tagged E.coli Human GST 721-837 a.a.
KAT2A-2129H Recombinant Human K(lysine) Acetyltransferase 2A, His-tagged Insect Cells Human His
KAT2A-2132H Recombinant Human KAT2A protein, GST-tagged Wheat Germ Human GST 1-837 a.a.
KAT2A-29886TH Recombinant Human KAT2A, His-tagged E.coli Human His 427 amino acids
KAT2A-005H Recombinant Human KAT2A Protein, His-tagged Insect Cells Human His 2-837
KAT2A-058H Recombinant Human KAT2A Protein, His-tagged Insect Cells Human His 2-837
KAT2A-080H Recombinant Human lysine acetyltransferase 2A Protein, His tagged E.coli Human His 497-662aa
KAT2A-2352H Recombinant Human KAT2A Protein, His-tagged E.coli Human His Ala648-Lys837
KAT2A-290HCL Recombinant Human KAT2A HEK293T cell lysate HEK293 Human Myc&DDK
KAT2A-679HF Recombinant Full Length Human KAT2A Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 837 amino acids

    Involved Pathway

    KAT2A involved in several pathways and played different roles in them. We selected most pathways KAT2A participated on our site, such as Notch signaling pathway,Thyroid hormone signaling pathway,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway CNTN6,HDAC2,DLL4,CTBP2,PSEN1,DLK1,NOTCH1B,NCSTN,LNX1,MIB1
    Thyroid hormone signaling pathway GSK3B,ATP1B2,PRKACA,AKT2,RCAN1,TBC1D4,ACTB,MED12L,SLC16A2,ITGAV
    HTLV-I infection RRAS,XIAP,PRKACG,WNT7A,FZD8,TLN1,MAPK8,TRP53,CD3D,POLE
    Viral carcinogenesis PSMC1,HLA-F,ACTN3,HIST1H2BD,HIST1H4G,HLA-E,RB1,GTF2E1,HIST2H4A,CDC20

    Protein Function

    KAT2A has several biochemical functions, for example, H3 histone acetyltransferase activity,chromatin binding,histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT2A itself. We selected most functions KAT2A had, and list some proteins which have the same functions with KAT2A. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor binding FOXO4,NR0B2A,HDAC2,DIP2B,ERCC3,HES4,NLK,TAF7,GTF2A2,KLF5
    H3 histone acetyltransferase activity BRCA2,ELP3
    transcription coactivator activity BRCA1,PML,MYOD1,ESRRB,JUNB,E4F1,TRIP4,MED23,MED7,GRIP1
    histone deacetylase binding SIX3,ZNHIT1,DNMT3B,RAD9,MEF2D,YWHAB,BRMS1,RELA,NRIP1,YWHAE
    protein phosphatase binding GRB2,PPP6R3,IRS2,HSF4,ERBB2,FLT4,PPP1R3G,PIK3R1,PIK3R2,KCNN4
    contributes_to histone acetyltransferase activity SAP130,TAF5L,TADA1,TAF12,TADA2B,TAF9,TEX30,SUPT7L,TAF6L,ELP4
    protein binding KSR1,SEC61G,MBIP,LGALS2,C6orf108,ZFYVE19,SUPT5H,GORASP2,NEU4,WEE1
    histone acetyltransferase activity KAT5,CLOCK,ATF2,KAT6B,KAT2B,HTATIP,MGEA5,EP300,NCOA2,TAF1L
    chromatin binding NR5A1,TP63,SOX9,ASF1A,CDK9,ADNP,POU1F1,EBF2,ATF2,ATAD2B

    Interacting Protein

    KAT2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT2A here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT2A.

    TRRAP;WDHD1;ATXN7;BRCA1

    Resources

    Research Area

    Histone Acetyltransferases and Associated Proteins

    References

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