Jam3
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Official Full Name
junctional adhesion molecule 3 -
Overview
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants. -
Synonyms
JAM3;junctional adhesion molecule 3;junctional adhesion molecule C;JAM C;JAMC;FLJ14529;JAM 2;JAM 3;JAM2;Junctional adhesion molecule 3 precursor;JAM-2;JAM-3;OTTHUMP00000235250;OTTHUMP00000235251;JAM-C
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian cells
- Mammalian Cell
- HEK293
- E.coli
- Human Cell
- HEK293T
- Fc
- His
- Non
- His&GST
- His&T7
- His&Fc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
Jam3 involved in several pathways and played different roles in them. We selected most pathways Jam3 participated on our site, such as Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with Jam3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | MHC2DCB,PRPSAP2,CLDN18,NRXN3,CLDNE,BF2,CLDN8,PTPRM,CLDN16,ITGB1A |
| Tight junction | CLDN19,YES1,PPP2R2C,CLDN20,CLDN11B,MPP5A,PRKCQ,PARD6GA,CLDN5A,EPB41L3 |
| Leukocyte transendothelial migration | CD99,GNAI1,CYBA,PRKCA,CLDN2,ACTN3,RASSF5,CLDN14,CDH5,VAV2 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V0A2,PLCG1,MAP3K14,GIT1,ATP6V1C1,MAPK10,NFKB1,NOD1,PAK1,IKBKG |
Protein Function
Jam3 has several biochemical functions, for example, integrin binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Jam3 itself. We selected most functions Jam3 had, and list some proteins which have the same functions with Jam3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | PRDX4,RXRB,PEX11B,PVR,BCL2L10,CAMK2A,AMBP,GPD1C,DPP4,TSG101 |
| protein binding | CDK9,IFT122,ZMYND19,PRPS2,C5orf13,C1orf51,UBA5,KLF4,RBM39,PSPC1 |
| integrin binding | COL5A1,FBN1,IGF1,ITGA6,ITGB1BP1,ECM2,Tcam1,CYR61L1,COL16A1,ADAMTS13 |
| protein heterodimerization activity | FZD9,RXRA,GAD2,MID2,TCF4,BMP7A,APITD1,TIMELESS,HIST1H2BN,SIM2 |
Interacting Protein
Jam3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Jam3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Jam3.
JAM2;PARD3
Resources
Research Area
Other CD AntigenImmunoglobulin Superfamily CAMs
Tight Junction Proteins in Endothelial Cells
Tight Junction Proteins in VSMC
Epithelial Cell Markers and Intracellular Molecules
Tight Junctions
Related Services
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References
