JMJD6
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Official Full Name
jumonji domain containing 6 -
Overview
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
JMJD6;jumonji domain containing 6;PSR;PTDSR;PTDSR1;bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;lysyl-hydroxylase JMJD6;phosphatidylserine receptor;jmjC domain-containing protein 6;histone arginine demethylase JMJD6;peptide-lysine 5-dioxygenase JMJD6;jumonji domain-containing protein 6
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian cells
- Mammalian Cell
- HEK293
- HEK293T
- His
- Flag
- His&T7
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
JMJD6 involved in several pathways and played different roles in them. We selected most pathways JMJD6 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with JMJD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | KAT7A,KDM5BA,CSRP2BP,SAP30,KDM1A,ATXN7L3,CAPNS2,KDM4C,BRD8,DPY30 |
| Chromatin modifying enzymes | RBBP7,ING5A,EPC1,SMARCC1,MEAF6,BRD1,MSL1A,ING3,MSL3,SMARCD3 |
| HDMs demethylate histones | KDM5C,KDM7AB,KDM2B,KDM2AA,KDM4C,KDM4B,KDM6AL,KDM4A,KDM3B,KDM5BA |
Protein Function
JMJD6 has several biochemical functions, for example, RNA binding,histone demethylase activity (H3-R2 specific),histone demethylase activity (H4-R3 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by JMJD6 itself. We selected most functions JMJD6 had, and list some proteins which have the same functions with JMJD6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | RPS25,DZIP3,DDX53,ZRANB2,ZFP385C,FAU,EIF4E3,SRSF9,DDX3X,PAPOLB |
| protein binding | TYROBP,NEU2,TESK1,PTPN14,FKBP2,TRIM41,GAS6,KLRD1,PPARD,DDX17 |
| single-stranded RNA binding | TLR8,HNRNPA1,HMGB1,A1CF,IFIH1,DHX58,DDX58,ANXA1,LONP1,LUZP4 |
| receptor activity | NR2C2,EDA2R,ATP6AP2,PAQR5B,GUCY1B3,IL10RB,VPREB1,MED24,NR2C1,LYVE1 |
| identical protein binding | ETNPPL,TRIM39,CCT7,DESI1,AHCY,FZD1,HNRNPC,KCNIP2,GBP5,TPRG1L |
| iron ion binding | CYP4V7,CYP2B6,FA2H,CYP21A2,ALOX15,OGFOD1,FAXDC2,CYP2C70,ALOX12E,CYP7B1 |
Interacting Protein
JMJD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JMJD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of JMJD6.
BRD4;FRMD6;NAA50;CDK9
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References
- Neumann, B; Coakley, S; et al. EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway. NATURE 517:219-U259(2015).
- Yang, HW; Chen, YZ; et al. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. NATURE COMMUNICATIONS 6:-(2015).
