HYAL1
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Official Full Name
hyaluronoglucosaminidase 1 -
Overview
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HYAL1;hyaluronoglucosaminidase 1;hyaluronidase-1;FUS2;HYAL 1;LUCA1;NAT6;Hyal-1;HYAL1_HUMAN;Hyaluronidase 1;Hyaluronoglucosaminidase-1;Hyaluronoglucosaminidase1;LUCA 1;LUCA-1;Lung carcinoma protein 1;MGC45987;Plasma hyaluronidase;Tumor suppressor LUCA 1;tumor suppressor LUCA-1
Recombinant Proteins
- Human
- Bovine
- Rat
- Mouse
- CHO
- Bovine Testis
- HEK293
- Wheat Germ
- Mammalian Cell
- E.coli
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- Yeast
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
HYAL1 involved in several pathways and played different roles in them. We selected most pathways HYAL1 participated on our site, such as Glycosaminoglycan degradation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | C1GALT1B,FOLH1,CBSA,PIK3C3,NDST4,UMPS,GCNT4,ST3GAL1,OXSR1,POLR3B |
| Glycosaminoglycan degradation | IDS,IDUA,NAGLU,HEXB,HYAL6,HYAL4,HEXA,SGSH,HGSNAT,HPSE2 |
| Lysosome | MFSD8,ABCB9,LAMP2,ATP6AP1,ATP6V0CB,TPP1,SMPD1,LAMP1,CTSL1B,AP4S1 |
Protein Function
HYAL1 has several biochemical functions, for example, hyaluronan synthase activity,hyalurononglucosaminidase activity,NOT hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL1 itself. We selected most functions HYAL1 had, and list some proteins which have the same functions with HYAL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hyalurononglucosaminidase activity | KIAA1199,CD44,MGEA5,HYAL2,HYAL4,HYAL3,SPAM1,HYAL6 |
| NOT hyalurononglucosaminidase activity | HYAL3,HYAL2 |
| transcription factor binding | NFYC,IFI203,PER1,E2F4,SNF8,NKX2-5,APBB2,EGR1,STK36,TAF12 |
| hyaluronan synthase activity | HAS1,HAS3,HAS2 |
| NOT virus receptor activity | HYAL3 |
Interacting Protein
HYAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL1.
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References
- Schmaus, A; Sleeman, JP; et al. Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid. GLYCOBIOLOGY 25:258-268(2015).
- Colombaro, V; Jadot, I; et al. Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover. ACTA HISTOCHEMICA 117:83-91(2015).
