HTRA4
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Official Full Name
HtrA serine peptidase 4 -
Overview
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. -
Synonyms
HTRA4;HtrA serine peptidase 4;probable serine protease HTRA4;FLJ90724;High temperature requirement protean A4;HTRA 4;OTTHUMP00000225766
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Insect Cell
- Mammalian Cell
- HEK293
- Insect Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
HTRA4 involved in several pathways and played different roles in them. We selected most pathways HTRA4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HTRA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HTRA4 has several biochemical functions, for example, endopeptidase activity,insulin-like growth factor binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTRA4 itself. We selected most functions HTRA4 had, and list some proteins which have the same functions with HTRA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | ADAMTS3,ACE2,MMP1,KLK1B11,ATG4B,SENP5,TRAPPC12,NAPSA,PSMA3,REN2 |
| serine-type endopeptidase activity | GZMB,ST14B,TPP2,TMPRSS4,MASP1,RHBDD3,PCSK7,MCPT2,TYSND1,PLAU |
| insulin-like growth factor binding | HTRA3,Igfbpl1,HTRA3A,CTGF,DEFB126,IGF1RB,ESM1,IGFBP5A,CTGFB,IGFALS |
Interacting Protein
HTRA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTRA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTRA4.
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