HSPBP1
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Official Full Name
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -
Overview
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. -
Synonyms
HSPBP1;HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1;hsp70-binding protein 1;FES1;Hsp70 binding protein 1;hsp70 interacting protein;1500019G21Rik;Heat shock protein 70 binding protein;Heat shock protein 70 interacting protein;Heat shock protein binding protein 1;Heat shock protein-binding protein 1;Heat-shock 70-KD protein-binding protein 1;HPBP1_HUMAN;Hsp 70 binding protein;Hsp 70 interacting protein;Hsp70 binding protein 2;Hsp70 interacting protein 1;Hsp70 interacting protein 2;Hsp70-binding protein 2;Hsp70-interacting protein 1;Hsp70-interacting protein 2;HSPA-binding protein 1;HSPBP;HspBP2;PP1845
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cell
- E.coli
- Human
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- T7
- Non
- GST
- His&GST
- His&Fc&Avi
Involved Pathway
HSPBP1 involved in several pathways and played different roles in them. We selected most pathways HSPBP1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | CALR3B,ERN1,UBE2D2,DNAJB1,EDEM1,MAPK8B,HSP90AB1,PLAA,NFE2L2,CANX |
Protein Function
HSPBP1 has several biochemical functions, for example, adenyl-nucleotide exchange factor activity,enzyme inhibitor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPBP1 itself. We selected most functions HSPBP1 had, and list some proteins which have the same functions with HSPBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adenyl-nucleotide exchange factor activity | GRPEL2,GRPEL1,PFN2,PFN1,SIL1 |
| enzyme inhibitor activity | SCG5,PDE6G,ANGPTL4,SLN,WFIKKN1,KIAA1967,GCHFR,ATPIF1,WDTC1,UGT1A1 |
| protein binding | MRPL20,HSPE1,ZNF843,USP1,C19orf47,SNX19,LSAMP,HILPDA,C2orf29,C1QL1 |
Interacting Protein
HSPBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPBP1.
HSPA8;HSPA2;NOTCH2NL;HSPA8
Resources
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References
- Hromadnikova, I; Dvorakova, L; et al. Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels. MOLECULAR BIOLOGY REPORTS 42:625-637(2015).
- Solodkov, AP; Lazuko, SS; et al. Changes in the Profile of NO Synthases Affect Coronary Blood Flow Autoregulation and Myocardial Contractile Activity during Restraint Stress in Rats. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 158:200-205(2014).
