HSF2
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Official Full Name
heat shock transcription factor 2 -
Overview
Heat shock factor 2 (Hsf2) belongs to a family of heat shock transcription factors that activate the transcription of genes encoding products required for protein folding, processing, targeting, degradation, and function. The up-regulation of heat shock protein (Hsp) expression by stressors is achieved at the level of transcription through a heat shock element (HSE) and a transcription factor. Most Hsfs have highly conserved amino acid sequences. On all Hsfs there is a DNA binding domain at the N-terminus. Hydrophobic repeats located adjacent to this binding domain are essential for the formation of active trimers. Towards the C-terminal region another short hydrophobic repeat exists and is thought to be necessary for suppression of trimerization. There are two main Hsfs, 1 and 2. Murine Hsf1 exists as two isoforms, however in higher eukaryotes Hsf1 is found in a diffuse cytoplasmic and nuclear distribution in unstressed cells. Once exposed to a multitude of stressors, it localizes to discrete nuclear granules within seconds. As it recovers from stress, Hsf1 dissipates from these granules to a diffuse nucleoplasmic distribution. Hsf2 on the other hand is similar to murine Hsf1, as it exists as two isoforms, the a form being more transcriptionally active than the smaller b form. Various experiments have suggested that Hsf2 may have roles in differentiation and development. -
Synonyms
HSF2;heat shock transcription factor 2;heat shock factor protein 2;HSF 2;HSTF 2;MGC75048;MGC117376;MGC156196
Recombinant Proteins
- Chicken
- Human
- Rat
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
HSF2 involved in several pathways and played different roles in them. We selected most pathways HSF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HSF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HSF2 has several biochemical functions, for example, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSF2 itself. We selected most functions HSF2 had, and list some proteins which have the same functions with HSF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | MNT,STIL,SMARCA4,TAF5L,ABRA,KDM5A,PER2,SCAND1,MKL1,FHL5 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | BARX2,HIF1A,IKZF3,EP300,RFX6,LMO2,SOX17,SLAMF7,GRHL3,NEUROD2 |
| protein binding | GFI1B,C11orf68,KANSL2,EPM2A,SPRR3,APP,DARS2,PRKCD,TBX18,CLASP1 |
| RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | SMYD3,ZC3H8,NCOA2,HSF1,ZNF350,VAX1,VAX2 |
| protein homodimerization activity | TIGIT,PRPS1,GIMAP7,SP1,PYCARD,XPNPEP1,CLN6,SNRPC,CD8A,CADM4 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF561,ZBTB4,DBP,PLAGL1,POU3F4,SKINT8,ELF5,ACTN4,AASS,BARHL1A |
| transcription factor activity, sequence-specific DNA binding | ZNF561,THRA,STAT2,MAP3K7,MEF2B,MAFGA,TSC22D2,ZNF436,ETV5A,MYCLA |
Interacting Protein
HSF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSF2.
TPM3;NUP62;WDR5;TPM3;EIF2C2;IRS4;TET3;FBXO24;URI1;BAG4;BAG2;BAG3
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References
- Heubeck, B; Wendler, O; et al. Tumor-associated antigenic pattern in squamous cell carcinomas of the head and neck - Analysed by SEREX. EUROPEAN JOURNAL OF CANCER 49:E1-E7(2013).
- Locke, M; et al. Heat shock protein accumulation and heat shock transcription factor activation in rat skeletal muscle during compensatory hypertrophy. ACTA PHYSIOLOGICA 192:403-411(2008).
