HSD17B12
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Official Full Name
hydroxysteroid (17-beta) dehydrogenase 12 -
Overview
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. -
Synonyms
HSD17B12;hydroxysteroid (17-beta) dehydrogenase 12;estradiol 17-beta-dehydrogenase 12;3 ketoacyl CoA reductase;KAR;SDR12C1;short chain dehydrogenase/reductase family 12C;member 1;17 beta HSD 12;17 beta hydroxysteroid dehydrogenase 12;17-@beta-HSD XII;17-@beta-hydroxysteroid dehydrogenase XII;17-beta-HSD 12;17-beta-hydroxysteroid dehydrogenase 12;17beta HSD type 12;3-ketoacyl-CoA reductase;DHB12_HUMAN;Estradiol 17 beta dehydrogenase 12;KIK-I;Kik1;Short chain dehydrogenase/reductase family 12Cmember 1;Steroid dehydrogenase homolog;17beta-HSD type 12;OTTHUMP00000232808;short chain dehydrogenase/reductase family 12C, member 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Anas platyrhynchos (Mallard) (Anas boschas)
- Macaca fascicularis
- Bovine
- Mus musculus
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E.coli expression system
- His
- His&GST
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
HSD17B12 involved in several pathways and played different roles in them. We selected most pathways HSD17B12 participated on our site, such as Fatty acid elongation,Steroid hormone biosynthesis,Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid elongation | ELOVL1B,ELOVL4,TECR,ELOVL5,HADHAA,ELOVL3,ELOVL7B,HADH,PPT1,ELOVL2 |
| Fatty acid metabolism | ACSL1B,HSD17B12B,HADHA,CPT2,ELOVL5,TECR,HSD17B12A,ACAA1A,PTPLAD2,PTPLA |
| Biosynthesis of unsaturated fatty acids | HADHA,ACAA1A,HSD17B12B,PTPLA,SCDB,ACOT2,ACOX3,TECRB,ACAA1,FADS2 |
| Steroid hormone biosynthesis | UGT2A2,CYP3A41A,UGT1A4,CYP2B19,CYP2C37,CYP7B1,UGT1A9,HSD17B2,HSD3B4,SRD5A2B |
| Metabolic pathways | AGPAT5,FAH,SGMS2,PLA2G2D,CYP51A1,ST8SIA1,ATP6V0E,DCTPP1,ATP5A1,APIP |
Protein Function
HSD17B12 has several biochemical functions, for example, collagen binding,estradiol 17-beta-dehydrogenase activity,fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B12 itself. We selected most functions HSD17B12 had, and list some proteins which have the same functions with HSD17B12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| estradiol 17-beta-dehydrogenase activity | HSD17B12B,HSD17B10,RDH8B,AKR1B15,H2-KE6,RDH8A,HSD17B12A,AKR1C6,HSD17B8,HSD17B6 |
| collagen binding | SPARC,SMAD3,Pdgfa&Pdgfb,LRRC15,ANTXR1,MMP9,CTSL1,TGFBI,MMP13,NID1 |
| fibronectin binding | MFAP2,ITGB3,IGFBP5B,LPA,THBS1,MYOC,FSTL3,CTGF,CTSK,ITGB1A |
| heparin binding | NELL2,CXCL13,SERPINE2,MSTN,CYR61L1,CLEC3B,APPA,FBLN7,FGFBP1,APLP2 |
| protein binding | AIP,ATG4B,PRCP,POP7,GPM6A,C10orf46,RFPL3,MT3,RAD52,KLHL18 |
Interacting Protein
HSD17B12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B12 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B12.
UBQLN1;UBQLN1;vpu;CLN3;1C;BECN1;P;HDAC11;SLC38A1
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References
- Li, Z; Van, LT; et al. Expression of enzymes involved in synthesis and metabolism of estradiol in human breast as studied by immunocytochemistry and in situ hybridization. HISTOLOGY AND HISTOPATHOLOGY 24:273-282(2009).
- Brown, KA; Sayasith, K; et al. Molecular cloning of equine 17 beta-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo. JOURNAL OF MOLECULAR ENDOCRINOLOGY 38:67-78(2007).
