HSD17B1
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Official Full Name
hydroxysteroid (17-beta) dehydrogenase 1 -
Overview
Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene. -
Synonyms
HSD17B1;hydroxysteroid (17-beta) de-hydrogenase 1;HSD17;EDHB17;EDH17B2;SDR28C1;MGC138140;estradiol 17-beta-dehydrogenase 1;E2DH;20-alpha-HSD;17-beta-HSD 1;20 alpha-hydroxysteroid dehydrogenase;17-beta-hydroxysteroid dehydrogenase type 1;placental 17-beta-hydroxysteroid dehydrogenase;hydroxyster-oid (17-beta) dehydrogenase 1 isoform;short chain dehydrogenase/reductase family 28CE, member 1
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- His&SUMO
- N-His&C-Myc
- Flag
Involved Pathway
HSD17B1 involved in several pathways and played different roles in them. We selected most pathways HSD17B1 participated on our site, such as Steroid hormone biosynthesis,Metabolic pathways,Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Steroid hormone biosynthesis | SRD5A2A,CYP19A1A,HSD3B4,UGT2A3,HSD3B5,CYP2C38,UGT2B7,SULT2B1,CYP7B1,SRD5A1 |
| Metabolic pathways | NT5C1B,HAL,MTHFR,H6PD,PLCG2,SPS2,DGKD,NDUFA13,ACO1,MTMR2 |
| Ovarian steroidogenesis | HSD3B2,INS2,HSD3B1,LDLR,INS,BMP15,LHCGR,HSD3B6,AKR1C3,HSD17B2 |
Protein Function
HSD17B1 has several biochemical functions, for example, catalytic activity,estradiol 17-beta-dehydrogenase activity,testosterone dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B1 itself. We selected most functions HSD17B1 had, and list some proteins which have the same functions with HSD17B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| catalytic activity | PGAM1,CDYL,HPGD,SLC3A2A,DBH,NANSA,SULF2A,Amy1,AGXTA,RAG1 |
| testosterone dehydrogenase (NAD+) activity | AKR1C3,HSD17B2,DHRS9,HSD17B6,H2-KE6,HSD17B8 |
| estradiol 17-beta-dehydrogenase activity | HSD17B6,HSD17B10,RDH8A,RDH8B,HSD17B12A,HSD17B7,HSD17B2,HSD17B12B,HSD17B11,HSD17B8 |
Interacting Protein
HSD17B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B1.
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