HS2ST1
-
Official Full Name
heparan sulfate 2-O-sulfotransferase 1 -
Overview
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. -
Synonyms
HS2ST1;heparan sulfate 2-O-sulfotransferase 1;KIAA0448;2OST;2-O-sulfotransferase;dJ604K5.2;FLJ11317;MGC131986
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- Xenopus laevis
- Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
- CHO
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- E.coli expression system
- HIS
- His
- GST
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
HS2ST1 involved in several pathways and played different roles in them. We selected most pathways HS2ST1 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, which may be useful for your reference. Also, other proteins which involved in the same pathway with HS2ST1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | GLCEA,HS3ST5,HS6ST3B,XYLT2,EXT1C,B4GALT7,HS3ST3B1,NDST1,HS6ST1B,HS3ST1L1 |
Protein Function
HS2ST1 has several biochemical functions, for example, heparan sulfate 2-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HS2ST1 itself. We selected most functions HS2ST1 had, and list some proteins which have the same functions with HS2ST1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparan sulfate 2-O-sulfotransferase activity | HS3ST1L2,HS6ST1A,HS6ST1B,CHST3A,HS3ST3L,SULT3ST4,HS6ST3B,SULT2ST1,SULT5A1,SULT2ST2 |
Interacting Protein
HS2ST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HS2ST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HS2ST1.
ssrna_ag
Resources
Related Services
Related Products
References
- Nakayama, F; Hagiwara, A; et al. Hydrogen peroxide as a potential mediator of the transcriptional regulation of heparan sulphate biosynthesis in keratinocytes. CELLULAR & MOLECULAR BIOLOGY LETTERS 13:475-492(2008).
