HPN
-
Official Full Name
hepsin -
Overview
This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] -
Synonyms
HPN;hepsin;TMPRSS1;serine protease hepsin;transmembrane protease serine 1
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- Mammalian cells
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- Non
- His
- GST
- His&Fc&Avi
Involved Pathway
HPN involved in several pathways and played different roles in them. We selected most pathways HPN participated on our site, such as Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | HIST1H2BA,GTF2H4,SRF,SND1,RANBP1,MAPKAPK2,LYN,PIK3CA,MRPS18B,VDAC3 |
Protein Function
HPN has several biochemical functions, for example, calcium-activated potassium channel activity,peptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPN itself. We selected most functions HPN had, and list some proteins which have the same functions with HPN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TFF1,RCC2,FAM127C,CDKAL1,GNE,EXOC3L,AMELX,THBS2,C11orf67,KMT2E |
| serine-type endopeptidase activity | PRSS59.2,GZMA,PREPL,CELA3A,TMPRSS4B,CTRC,PCSK7,LONP1,CTRB1,HTRA1A |
| serine-type exopeptidase activity | PREP,PREPL |
| serine-type peptidase activity | PLAUB,NAALAD2,KLK10,KLK7,GZMK,KLK1B9,PRSS44,DPP9,PRSS21,ST14 |
| calcium-activated potassium channel activity | CCT8L2,KCNMA1A,PKD2L1,KCNN1,KCNMB1,KCNMA1,KCNMB2,KCNN2,KCNK18,KCNN1B |
| peptidase activity | TPP1,CTSG,CAPN1A,DESI2,PPPDE1,CLCA5,CAPN3B,KLK7,FAM49BA,KLK1B16 |
Interacting Protein
HPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPN here. Most of them are supplied by our site. Hope this information will be useful for your research of HPN.
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References
- Sowinski, P; Piorkowska, E; et al. The role of nucleating agents in high-pressure-induced gamma crystallization in isotactic polypropylene. COLLOID AND POLYMER SCIENCE 293:665-675(2015).
- Klek, S; Szczepanek, K; et al. Taurolidine Lock in Home Parenteral Nutrition in Adults: Results From an Open-Label Randomized Controlled Clinical Trial. JOURNAL OF PARENTERAL AND ENTERAL NUTRITION 39:331-335(2015).
