HNRNPC
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Official Full Name
heterogeneous nuclear ribonucleoprotein C (C1/C2) -
Overview
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. -
Synonyms
HNRNPC;heterogeneous nuclear ribonucleoprotein C (C1/C2);HNRPC;heterogeneous nuclear ribonucleoproteins C1/C2;hnRNP C1/C2;nuclear ribonucleoprotein particle C1 protein;nuclear ribonucleoprotein particle C2 protein;C1;C2;HNRNP;SNRPC;MGC1
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Human
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HNRNPC involved in several pathways and played different roles in them. We selected most pathways HNRNPC participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | DHX15,SNRNP40,CRNKL1,THOC4,TCERG1A,SNRPB2,SNRPC,PUF60A,PRPF18,CCDC12 |
Protein Function
HNRNPC has several biochemical functions, for example, N6-methyladenosine-containing RNA binding,RNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPC itself. We selected most functions HNRNPC had, and list some proteins which have the same functions with HNRNPC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | SRSF1,ALG13,NAP1L1,TRUB2,FAM98B,NOM1,RBM12,NOP2,HMGB2,RBM10 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | FLI1,ESRRB,TAL1,PROP1,RUVBL2,PBX3,TFAP2C,NFE2L2,BACH2,ARID3B |
| mRNA 3-UTR binding | PUM2,FXR1,RNPS1,ELAVL2,CPEB1,RBM4,RBM38,CSDA,IGF2BP3,IGF2BP1 |
| protein binding | PPP1R1A,UBE2D2A,TNPO1,NF2,TNPO3,SLC4A1A,NAA35,TSR2,CDKN2AIP,CXorf48 |
| N6-methyladenosine-containing RNA binding | YTHDF1,YTHDC1,YTHDF2,YTHDF3 |
| nucleotide binding | DHX33,PPIP5K2,PHKG1B,RHOU,RBM47,APOA1BP,MSI2,SLC27A3,ZCRB1,AKAP17A |
| identical protein binding | DCTPP1,CEP170L,KRTAP10-5,KHDC1A,MUL1A,APLP1,CDC42,SCUBE1,ATXN3,TPRGL |
| telomerase RNA binding | DKC1,HNRNPU,NOP10,NHP2,PINX1,TERT,WRAP53,GAR1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF562,PATZ1,ELK1,ATF4,MYC,NR1H2,JUNB,ONECUT2,ZNF718,FLI1 |
Interacting Protein
HNRNPC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPC here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPC.
RALYL;KPNA3;RBM41
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