HMGCS1
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Official Full Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -
Synonyms
HMGCS1;3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble);3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble) , HMGCS;hydroxymethylglutaryl-CoA synthase, cytoplasmic;3 hydroxy 3 methylglutaryl coenzyme A (HMG CoA) synthase;cytoplasmic;3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble);3-hydroxy-3-methylglutaryl coenzyme A synthase;EC 2.3.3.10;HMCS1_HUMAN;HMG CoA synthase;HMG-CoA synthase;HMGCS;Hydroxymethylglutaryl CoA synthase, cytoplasmic;Hydroxymethylglutaryl-CoA synthase;MGC90332;3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase;3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- Yeast
- HEK293
- HEK293T
- His
- His&T7
- Non
- GST
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
HMGCS1 involved in several pathways and played different roles in them. We selected most pathways HMGCS1 participated on our site, such as Synthesis and degradation of ketone bodies,Valine, leucine and isoleucine degradation,Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Synthesis and degradation of ketone bodies | HMGCLL1,OXCT1B,HMGCS2,OXCT2A,ACAT2,ACAT1,OXCT2,HMGCL,OXCT2B,BDH1 |
| Metabolic pathways | ENPP3,NMRK1,CHIA.2,ATP5O,HADH,GGPS1,ATP5J,GLCEB,DAO.2,CYP1A |
| Valine, leucine and isoleucine degradation | OXCT2A,HIBADHB,HSD17B10,BCAT1,ALDH3A2A,OXCT1,ACAA1,ALDH6A1,ALDH2.1,HIBCH |
| Terpenoid backbone biosynthesis | HMGCRB,FNTA,HMGCS2,ACAT2,NUS1,MVK,PMVK,ZMPSTE24,GGPS1,IDI2 |
| Butanoate metabolism | EHHADH,GAD1B,AACS,ACSM5,ECHS1,GAD2,BDH1,ACSM4,HMGCS2,HADH |
Protein Function
HMGCS1 has several biochemical functions, for example, drug binding,hydroxymethylglutaryl-CoA synthase activity,isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCS1 itself. We selected most functions HMGCS1 had, and list some proteins which have the same functions with HMGCS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| isomerase activity | GPIB,HSD3B6,PPIAB,BPGM,TPI1A,TOP1L,PGAM1,ENOSF1,ITPK1A,ECI2 |
| protein homodimerization activity | UGT1A6,PYGB,CAT,DMRT2,ADRB3,CBX1,GABRR1,KIT,BMPR1A,TYMS |
| hydroxymethylglutaryl-CoA synthase activity | HMGCS2 |
| organic acid binding | HBA-A2 |
| drug binding | NAMPT,TLR7,GLRB,DRD1A,UGT1A7,ABP1,HMGB2,PYGL,DRD4,MT2A |
Interacting Protein
HMGCS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCS1.
IKBKE;sdhA;nrdD;polg_hcvjf_rna
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References
- Nakamura, T; Iwase, A; et al. CYP51A1 Induced by Growth Differentiation Factor 9 and Follicle-Stimulating Hormone in Granulosa Cells Is a Possible Predictor for Unfertilization. REPRODUCTIVE SCIENCES 22:377-384(2015).
- Oishi, K; Yamamoto, S; et al. Wheat Alkylresorcinols Suppress High-Fat, High-Sucrose Diet-Induced Obesity and Glucose Intolerance by Increasing Insulin Sensitivity and Cholesterol Excretion in Male Mice. JOURNAL OF NUTRITION 145:199-206(2015).
