HMGCR
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Official Full Name
3-hydroxy-3-methylglutaryl-CoA reductase -
Overview
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HMGCR;3-hydroxy-3-methylglutaryl-CoA reductase;3 hydroxy 3 methylglutaryl Coenzyme A reductase;3-hydroxy-3-methylglutaryl-Coenzyme A reductase;3 hydroxy 3 methylglutaryl CoA reductase (NADPH);hydroxymethylglutaryl CoA reductase;3H3M;MGC103269;HMDH_HUMAN;HMG CoA reductase;HMG CoAR;HMG-CoA reductase;Red;hydroxymethylglutaryl-CoA reductase;3-hydroxy-3-methylglutaryl CoA reductase (NADPH);LDLCQ3
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Insect Cell
- His
- GST
- Non
- His&Fc&Avi
- SUMO
Involved Pathway
HMGCR involved in several pathways and played different roles in them. We selected most pathways HMGCR participated on our site, such as Terpenoid backbone biosynthesis,Metabolic pathways,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | FAM84B,GNAS,OSTB,EPHX1,ABCG8,SLC10A2,ATP1B2,CA2,SLCO1B1,NCEH1 |
| AMPK signaling pathway | PRKAG1,CD36,ADRa1A,PIK3R5,PPP2R2C,CREB3,CREB1,MTOR,TSC1,AKT1S1 |
| Metabolic pathways | GOT1,GOT2B,NMNAT3,NDUFB8,Aldh1a7,ACAA1A,CRYL1,PDHX,SPAM1,ALG11 |
| Terpenoid backbone biosynthesis | PDSS2,MVD,MVDA,PMVK,FNTB,ACAT1,PDSS1,ZMPSTE24,HMGCS1,HMGCRB |
Protein Function
HMGCR has several biochemical functions, for example, NADPH binding,coenzyme binding,hydroxymethylglutaryl-CoA reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCR itself. We selected most functions HMGCR had, and list some proteins which have the same functions with HMGCR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | PCYT1A,SERPINF2,ASNSD1,CHKA,RPS19,CDA,BHLHB9,ASNS,SMAD2,CISD2 |
| protein phosphatase 2A binding | CTTNBP2NL,GRIN3A,MAPT,AKT1,SHC1,RPS6KB1,SMG5,CPD,STRN4,SPHK1 |
| hydroxymethylglutaryl-CoA reductase activity | HMGCRA,HMGCRB |
| NADPH binding | CBR4,KCNAB1,MTRR,GRHPR,QDPR,CRYZ,FASN,DHFR,DECR1,TP53I3 |
| protein binding | HSPE1,EFNA3,C19orf46,APBA2,C6orf226,AZIN1,NUDT18,CST7,TACC1,NCK2 |
| coenzyme binding | HMGCRA,GCH1,NDUFA9A,QDPRB1,WWOX,HMGCRB,TSTA3,ALAS2,ACAT1,TDH |
| hydroxymethylglutaryl-CoA reductase (NADPH) activity | HMGCRB,HMGCRA |
Interacting Protein
HMGCR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCR here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCR.
UBIAD1;q99ib8-pro_0000045602;STARD13;UBIAD1
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References
- Luo, YB; Mastaglia, FL; et al. Dermatomyositis, polymyositis and immune-mediated necrotising myopathies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:622-632(2015).
- Watanabe, Y; Suzuki, S; et al. Statins and Myotoxic Effects Associated With Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies An Observational Study in Japan. MEDICINE 94:-(2015).
