HIST2H4A
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Official Full Name
histone cluster 2, H4a -
Overview
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008] -
Synonyms
HIST2H4A;histone cluster 2, H4a;H4;H4/n;H4F2;H4FN;FO108;HIST2H4;histone H4;histone 2, H4a;H4 histone, family 2;histone IV, family 2;H4 histone family, member N
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HIST2H4A-129H | Recombinant Human HIST2H4A Protein, HIS-tagged | E.coli | Human | HIS |
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| HIST2H4A-303H | Recombinant Human Full Length HIST2H4A protein(Met1-Gly103) | E.coli | Human | Non | Full L. 1-103 a.a. |
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| HIST2H4A-4814H | Recombinant Human HIST2H4A Protein, GST-tagged | Wheat Germ | Human | GST |
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| HIST2H4A-5514HCL | Recombinant Human HIST2H4A 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
HIST2H4A involved in several pathways and played different roles in them. We selected most pathways HIST2H4A participated on our site, such as Alcoholism,Viral carcinogenesis,Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST2H4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | IRF3,TBP,IKBKG,GTF2H1,UBE3A,HIST1H2BF,PIK3CG,ACTN2,RELA,KAT2B |
| Alcoholism | H2AFV,H2AFB2,GRIN1,PKIA,GNG5,HIST1H4L,MAPK3,FOSB,HIST1H3D,HIST2H2AC |
| Systemic lupus erythematosus | HIST2H3C1,GM14483,FCGR4,HIST1H4A,TROVE2,HIST2H4,H2BFWT,GM6026,GM14478,ACTN1 |
Protein Function
HIST2H4A has several biochemical functions, for example, DNA binding,histone binding,histone demethylase activity (H4-K20 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by HIST2H4A itself. We selected most functions HIST2H4A had, and list some proteins which have the same functions with HIST2H4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone demethylase activity (H4-K20 specific) | HIST1H4F,HIST1H4J,HIST1H4H,HIST1H4K,PHF8,HIST1H4B,HIST1H4C,HIST1H4I,HIST4H4,HIST1H4A |
| protein domain specific binding | TUBB,PLXND1,STXBP1,CNOT1,IST1,MPP7,YWHAE2,TWIST1,VRK2,COX4I2 |
| histone binding | TONSL,HIST1H3A,SFMBT1,TBL1XR1,HIST1H3I,ZMYND11,JAK2,NFKBIL2,HIST4H4,HJURP |
| DNA binding | RABGAP1,ZNF180,PHC2B,CHD4,ZNF738,JARID2B,NUFIP1,HMGB2B,ESR2,HDX |
| poly(A) RNA binding | TXN,MRPL2,ZNFX1,GTPBP10,PABPC4,YWHAE,KCTD12,ZNF207,LRRC59,BRIX1 |
| protein binding | ORAI3,TTBK2,C1QL1,PI4KA,BIRC2,ERH,ANXA1,IL4,EDAR,BLNK |
| protein heterodimerization activity | NR2C2,CENPW,BTBD11,MYH7,KCNA3,PML,ZHX1,CHRNB2,FLOT2,GCA |
Interacting Protein
HIST2H4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST2H4A here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST2H4A.
KDM4A;TP53BP1;SETD8
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