HIBADH
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Official Full Name
3-hydroxyisobutyrate dehydrogenase -
Overview
This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. -
Synonyms
HIBADH;3-hydroxyisobutyrate dehydrogenase;3-hydroxyisobutyrate dehydrogenase, mitochondrial;NS5ATP1;EC 1.1.1.31;3 hydroxy 2 methylpropanoate:NAD(+) oxidoreductase;3 hydroxyisobutyrate dehydrogenase;3 hydroxyisobutyrate dehydrogenase mitochondrial;MGC40361
Recombinant Proteins
- Chicken
- Human
- Rat
- Mouse
- Mammalian Cell
- HEK293
- Wheat Germ
- E.coli
- HEK293T
- In Vitro Cell Free System
- His
- Myc&DDK
- GST
- Non
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
HIBADH involved in several pathways and played different roles in them. We selected most pathways HIBADH participated on our site, such as Branched-chain amino acid catabolism,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIBADH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Branched-chain amino acid catabolism | DBT,ALDH9A1A.2,HIBADHA,PPM1K,BCKDK,IVD,DLD |
| Metabolism of amino acids and derivatives | SLC25A15B,NAALAD2,SLC25A2,CKBA,DBH,CKM,PAOX,OAZ1,TPH2,CRYM |
| Metabolism | AK8,SPRB,ABHD10,INSIG2,ITPKB,DBH,AKR1C6,ARSJ,EBP,CYP2C18 |
| Valine, leucine and isoleucine degradation | MUT,HIBCH,OXCT1,ACAA1A,OXCT2B,AUH,HADHAB,ALDH3A2A,HSD17B10,MCCC1 |
| Metabolic pathways | PMVK,ATP6V0A1,CYP19A1,CERS5,PIGU,TWISTNB,MOCS2,NDUFV3,UQCRQ,NADKA |
Protein Function
HIBADH has several biochemical functions, for example, 3-hydroxyisobutyrate dehydrogenase activity,NAD binding,phosphogluconate dehydrogenase (decarboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HIBADH itself. We selected most functions HIBADH had, and list some proteins which have the same functions with HIBADH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | IDH3B,ADH1,GRHPRA,HADHA,CTBP2L,GPD1C,PARP1,UGDH,ME3,AOX1 |
| 3-hydroxyisobutyrate dehydrogenase activity | HIBADHA,HIBADHB |
| phosphogluconate dehydrogenase (decarboxylating) activity | HIBADHA,PGD,HIBADHB,GLYR1 |
Interacting Protein
HIBADH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIBADH here. Most of them are supplied by our site. Hope this information will be useful for your research of HIBADH.
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References
- Zou, J; Mi, L; et al. Interaction of 14-3-3 sigma with KCMF1 suppresses the proliferation and colony formation of human colon cancer stem cells. WORLD JOURNAL OF GASTROENTEROLOGY 19:3770-3780(2013).
