HGS
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Official Full Name
hepatocyte growth factor-regulated tyrosine kinase substrate -
Overview
Hepatocyte growth factor-regulated tyrosine kinase substrate . In order to perform this function, HRS is ubiquitinated at its ubiquitin interacting motif (UIM). This allows interaction of HRS with similarly ubiquitinated vesicle-related proteins such as STAM1 and Eps15, as well as ubiquitinated receptors tagged for lysosomal degradation. Complexes of HRS and STAM1 are located in vesicular membranes and regulate the sorting of tagged receptors to the lysosomes. -
Synonyms
HGS;hepatocyte growth factor-regulated tyrosine kinase substrate;Hrs;Vps27;ZFYVE8;protein pp110;human growth factor-regulated tyrosine kinase substrate;FLJ11421;FLJ39878
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
HGS involved in several pathways and played different roles in them. We selected most pathways HGS participated on our site, such as Endocytosis,Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HGS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | SFTPA1,HLA-DMB,TUBA1L2,RAC1B,DYNC2H1,ITGB1A,ATP6V1E1,H2-AB1,HLA-DRB5,CD209 |
| Endocytosis | STAMBP,PRKCI,IQSEC1,GRK1,ERBB3A,RAB4A,BIN1,HSPA8,ARPC5A,ARF6A |
Protein Function
HGS has several biochemical functions, for example, metal ion binding,protein binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HGS itself. We selected most functions HGS had, and list some proteins which have the same functions with HGS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | YWHAZ,ST13,HNRNPM,E2F4,TNFAIP1,Ar,NLRP1,CRB3,MECP2,XPO1 |
| metal ion binding | PLD6,NMRK1,PDE11A,TIMM10B,IRF2BP2,RXRBA,LACTB2,PM20D1,DNAJC21,ARMC1L |
| protein binding | NOSTRIN,MYL6B,LZTFL1,BCL2L16,DULLARD,GSG2,VIM,DRD1,SKP2,CDK5R2 |
Interacting Protein
HGS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HGS here. Most of them are supplied by our site. Hope this information will be useful for your research of HGS.
UBC;MIF4GD;LDOC1;DAZAP2
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References
- Niedojadlo, K; Hyjek, M; et al. Spatial and temporal localization of homogalacturonans in Hyacinthus orientalis L. ovule cells before and after fertilization. PLANT CELL REPORTS 34:97-109(2015).
- Fairfax, K; Mackay, IR; et al. BAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus. IUBMB LIFE 64:595-602(2012).
