HESX1
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Official Full Name
HESX homeobox 1 -
Overview
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. -
Synonyms
HESX1;HESX homeobox 1;homeobox, ES cell expressed 1;homeobox expressed in ES cells 1;ANF;RPX;hAnf;homeobox protein ANF;Rathke pouch homeobox;CPHD5
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HESX1-13749H | Recombinant Human HESX1, GST-tagged | E.coli | Human | GST | 1-185a.a. | |
| HESX1-2449H | Recombinant Human HESX1 protein, His-tagged | E.coli | Human | His | 1-185 aa | |
| HESX1-4708H | Recombinant Human HESX1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HESX1-6570C | Recombinant Chicken HESX1 | Mammalian Cell | Chicken | His |
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| HESX1-7592M | Recombinant Mouse HESX1 Protein | Mammalian Cell | Mouse | His |
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| HESX1-8932Z | Recombinant Zebrafish HESX1 | Mammalian Cell | Zebrafish | His |
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| HESX1-5579HCL | Recombinant Human HESX1 293 Cell Lysate | HEK293 | Human | Non |
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| Hesx1-1115M | Recombinant Mouse Hesx1 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| HESX1-3522HF | Recombinant Full Length Human HESX1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 185 amino acids |
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| HESX1-4137M | Recombinant Mouse HESX1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HESX1-4137M-B | Recombinant Mouse HESX1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| HESX1-4583H | Recombinant Human HESX1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
HESX1 involved in several pathways and played different roles in them. We selected most pathways HESX1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with HESX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | SMAD3,SMAD2,IGF1,FZD9,ACVR2A,BMPR1B,ACVR1B,WNT8A,FZD6,SMAD4 |
Protein Function
HESX1 has several biochemical functions, for example, DNA binding,chromatin binding,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HESX1 itself. We selected most functions HESX1 had, and list some proteins which have the same functions with HESX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | TOX3,POLE,SMARCD3,NKX6,RBPJ,SP3,ATF5,EP300,SIRT6,RFX4 |
| protein N-terminus binding | SERPINB1A,MAU2,PARP1,CHMP6,THAP7,KCNIP1,PEX19,SDCBP,STXBP1,ALG2 |
| sequence-specific DNA binding | NKX2.7,MEIS3,HLX1,TAF1,USF2,HOXC5,NR6A1,FOXD4L1,ZBTB4,FOXB1 |
| DNA binding | HNRNPU,CERS4,THAP4,ZFP488,THAP6,ASH2L,GLI4,ISX,ZNF2,HIST1H4G |
| protein binding | NUP155,UQCC2,EXOC3-AS1,TXNDC9,EXOSC8,Kitl,SLC22A2,FAM81B,MAP2,SYNDIG1 |
| protein C-terminus binding | NCL,ARL6IP5,HIC2,YAP1,MED12,VPS4B,TBL1X,MKI67,PEX10,DLG4 |
Interacting Protein
HESX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HESX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HESX1.
KDM1A;PRMT6;STAT3;STAT3
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References
- Takagi, M; Ishii, T; et al. A novel mutation in SOX3 polyalanine tract: a case of kabuki syndrome with combined pituitary hormone deficiency harboring double mutations in MLL2 and SOX3. PITUITARY 17:569-574(2014).
- Castinetti, F; Reynaud, R; et al. Combined pituitary hormone deficiency: current and future status. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 38:1-12(2015).
