HES1
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Official Full Name
hairy and enhancer of split 1, (Drosophila) -
Overview
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor;of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that;contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. -
Synonyms
HES1;hairy and enhancer of split 1, (Drosophila);hairy homolog (Drosophila) , HRY;transcription factor HES-1;bHLHb39;FLJ20408;HES 1;hairy homolog;hairy-like protein;class B basic helix-loop-helix protein 39;HHL;HRY;HES-1
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HES1 involved in several pathways and played different roles in them. We selected most pathways HES1 participated on our site, such as Fanconi anemia pathway,Notch signaling pathway,Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | HNF4A,NKX6-1,MNX1,INS2,INS,IAPP,FOXA3,FOXA2,PAX4,BHLHA15 |
| Fanconi Anemia Pathway | BRIP1,FUZ,STRA13,TOP3A,BLM,PALB2,HER6,FANCE,REV1,FANCL |
| Notch signaling pathway | RBPJ,MFAP5,DTX3L,NOTCH1B,DTX3,KAT2B,RFNG,ADAM17A,NUMBL,EP300 |
Protein Function
HES1 has several biochemical functions, for example, DNA binding,N-box binding,chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HES1 itself. We selected most functions HES1 had, and list some proteins which have the same functions with HES1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | PAX3,ZNF397,RORB,HOXC6B,RARGB,ETV1,ZNF323,NCOR1,FOXC1B,FLI1 |
| sequence-specific DNA binding | TLX3,ENG2A,SOX2,LHX6,HOXA2B,PPARAA,WHSC1,LHX3,SOX21A,ZBTB14 |
| chaperone binding | BIRC5,ATP1A3,DNAJB6,CLU,BAG2,BAX,BAK1,HSPD1,HSPE1,TG |
| histone deacetylase binding | PARK2,TAL1,SP1,GCM1,MAGEA2,KAT2B,SUDS3,ZFP932,TOP2A,HDAC3 |
| protein homodimerization activity | HARS2,NPM1,PDK2,DLK2,TFAP2E,MAP3K12,ADRA2A,CCL5,PRDM6,CAT |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | KCNIP3,MZF1,FOXO1,ETS2,ZBTB7A,ATF3,OVOL1,ZFP746,PPARA,ASCL2 |
| DNA binding | GLIS2,GATA5,EOMES,ZFP654,DUX3,Arid4b,POLL,ABT1,ZNF670,RARGA |
| transcription factor binding | RELA,TBP,PPP1R13BA,PPARGC1A,SOX17,KLF5,DIP2C,AGTR2,SORBS3,GTF2A2 |
| protein binding | PRKCB,RXFP4,FBXO9,MVK,CTSG,ABCD1,IGF2BP3,EPS15L1,TFB1M,ITGB4 |
Interacting Protein
HES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HES1.
SIRT1;NUDT3;APCS;GAPDH;ASGR2;NR4A1;YWHAB;HMGCL;LTBR;CSNK1E;PTK2;FHL1;q7cl30_yerpe;moeA2;APH1A;HDAC6
HES1 Related Signal Pathway
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References
- Otti, GR; Saleh, L; et al. Notch2 Controls Prolactin and Insulin-Like Growth Factor Binding Protein-1 Expression in Decidualizing Human Stromal Cells of Early Pregnancy. PLOS ONE 9:-(2014).
- Yan, B; Liu, L; et al. Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells. WORLD JOURNAL OF GASTROENTEROLOGY 20:13105-13118(2014).
